Allicin mitigates fumonisin B1-induced kidney toxicity in quails: Modulating fibrosis, NF-κB signaling pathway, and mitochondrial damage
Fumonisin B1 (FB1) is a common mycotoxin, which is a water-soluble metabolite produced through the metabolism of Fusarium verticillioides and Fusarium proliferator. Crops and feedstuffs are widely contaminated by FB1 from the environment, posing risks to livestock and human health. Currently, there...
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Elsevier
2025-08-01
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| Series: | Poultry Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579125005991 |
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| author | Yangwan Zhang Yihao He Xueyan Zhu Yang Liu Changyu Cao |
| author_facet | Yangwan Zhang Yihao He Xueyan Zhu Yang Liu Changyu Cao |
| author_sort | Yangwan Zhang |
| collection | DOAJ |
| description | Fumonisin B1 (FB1) is a common mycotoxin, which is a water-soluble metabolite produced through the metabolism of Fusarium verticillioides and Fusarium proliferator. Crops and feedstuffs are widely contaminated by FB1 from the environment, posing risks to livestock and human health. Currently, there is no therapeutic approach available for FB1 intoxication. Allicin, an organic sulfur compound extracted from garlic, exhibits anti-inflammatory, antioxidant, antibacterial, hepatoprotective, cardioprotective, and intestinal regulatory properties. However, investigations into allicin’s role in alleviating FB1-induced quail nephrotoxicity remain relatively limited. This study thus aimed to elucidate the mechanisms by which allicin exerts a protective effect against FB1-induced kidney injury in juvenile quails. A total of 150 juvenile quails were randomly divided into five groups and treated with varying allicin concentrations (0, 50, 100, 500, and 1000 mg/kg) for 8 weeks. The blood and kidney tissues were subsequently screened using serum biochemical indices and histological staining, which suggested that 500 mg/kg of allicin was the optimal concentration that exerts protection to the quail kidneys. Another 120 juvenile quail were randomly divided into four groups (n = 30): control, allicin, FB1, and allicin+FB1. The pathological changes in kidney tissues induced by FB1 and genes associated with nuclear xenobiotic receptors (NXRs), inflammation, fibrosis, and mitochondrial damage were evaluated after 8 weeks. FB1 triggered kidney fibrosis and mitochondrial injury by activating the NF-κB signaling pathway, modulating NXR expression, and regulating corresponding CYP450 subtypes, which culminated in pathological injury to kidney tissues. Notably, allicin alleviated FB1-induced kidney injury in quails, possibly by inhibiting the NF-κB pathway, fibrosis, and mitochondrial damage, suggesting the potential application of allicin in preventing FB1-induced toxicity in quail. |
| format | Article |
| id | doaj-art-857edcd2e75f4d71bb21c40bd2ab9600 |
| institution | DOAJ |
| issn | 0032-5791 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj-art-857edcd2e75f4d71bb21c40bd2ab96002025-08-20T02:50:09ZengElsevierPoultry Science0032-57912025-08-01104810535610.1016/j.psj.2025.105356Allicin mitigates fumonisin B1-induced kidney toxicity in quails: Modulating fibrosis, NF-κB signaling pathway, and mitochondrial damageYangwan Zhang0Yihao He1Xueyan Zhu2Yang Liu3Changyu Cao4College of Animal Science and Technology, Foshan University, Foshan Guangdong 528225, ChinaCollege of Animal Science and Technology, Foshan University, Foshan Guangdong 528225, ChinaCollege of Animal Science and Technology, Foshan University, Foshan Guangdong 528225, ChinaQuality Control Technical Center (Foshan) of National Famous and Special Agricultural Products (CAQS-GAP-KZZX043), College of Food Science and Engineering, Foshan University, Foshan Guangdong 528225, ChinaCollege of Animal Science and Technology, Foshan University, Foshan Guangdong 528225, China; Foshan University Veterinary Teaching Hospital, Foshan, Guangdong 528231, China; Corresponding author.Fumonisin B1 (FB1) is a common mycotoxin, which is a water-soluble metabolite produced through the metabolism of Fusarium verticillioides and Fusarium proliferator. Crops and feedstuffs are widely contaminated by FB1 from the environment, posing risks to livestock and human health. Currently, there is no therapeutic approach available for FB1 intoxication. Allicin, an organic sulfur compound extracted from garlic, exhibits anti-inflammatory, antioxidant, antibacterial, hepatoprotective, cardioprotective, and intestinal regulatory properties. However, investigations into allicin’s role in alleviating FB1-induced quail nephrotoxicity remain relatively limited. This study thus aimed to elucidate the mechanisms by which allicin exerts a protective effect against FB1-induced kidney injury in juvenile quails. A total of 150 juvenile quails were randomly divided into five groups and treated with varying allicin concentrations (0, 50, 100, 500, and 1000 mg/kg) for 8 weeks. The blood and kidney tissues were subsequently screened using serum biochemical indices and histological staining, which suggested that 500 mg/kg of allicin was the optimal concentration that exerts protection to the quail kidneys. Another 120 juvenile quail were randomly divided into four groups (n = 30): control, allicin, FB1, and allicin+FB1. The pathological changes in kidney tissues induced by FB1 and genes associated with nuclear xenobiotic receptors (NXRs), inflammation, fibrosis, and mitochondrial damage were evaluated after 8 weeks. FB1 triggered kidney fibrosis and mitochondrial injury by activating the NF-κB signaling pathway, modulating NXR expression, and regulating corresponding CYP450 subtypes, which culminated in pathological injury to kidney tissues. Notably, allicin alleviated FB1-induced kidney injury in quails, possibly by inhibiting the NF-κB pathway, fibrosis, and mitochondrial damage, suggesting the potential application of allicin in preventing FB1-induced toxicity in quail.http://www.sciencedirect.com/science/article/pii/S0032579125005991FB1AllicinQuailNephrotoxicity |
| spellingShingle | Yangwan Zhang Yihao He Xueyan Zhu Yang Liu Changyu Cao Allicin mitigates fumonisin B1-induced kidney toxicity in quails: Modulating fibrosis, NF-κB signaling pathway, and mitochondrial damage Poultry Science FB1 Allicin Quail Nephrotoxicity |
| title | Allicin mitigates fumonisin B1-induced kidney toxicity in quails: Modulating fibrosis, NF-κB signaling pathway, and mitochondrial damage |
| title_full | Allicin mitigates fumonisin B1-induced kidney toxicity in quails: Modulating fibrosis, NF-κB signaling pathway, and mitochondrial damage |
| title_fullStr | Allicin mitigates fumonisin B1-induced kidney toxicity in quails: Modulating fibrosis, NF-κB signaling pathway, and mitochondrial damage |
| title_full_unstemmed | Allicin mitigates fumonisin B1-induced kidney toxicity in quails: Modulating fibrosis, NF-κB signaling pathway, and mitochondrial damage |
| title_short | Allicin mitigates fumonisin B1-induced kidney toxicity in quails: Modulating fibrosis, NF-κB signaling pathway, and mitochondrial damage |
| title_sort | allicin mitigates fumonisin b1 induced kidney toxicity in quails modulating fibrosis nf κb signaling pathway and mitochondrial damage |
| topic | FB1 Allicin Quail Nephrotoxicity |
| url | http://www.sciencedirect.com/science/article/pii/S0032579125005991 |
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