Extracellular matrix: unlocking new avenues in cancer treatment
Abstract The extracellular matrix (ECM) plays a critical role in cancer progression by influencing tumor growth, invasion, and metastasis. This review explores the emerging therapeutic strategies that target the ECM as a novel approach in cancer treatment. By disrupting the structural and biochemica...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-05-01
|
| Series: | Biomarker Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40364-025-00757-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849704127073878016 |
|---|---|
| author | Jia Jing Lee Khuen Yen Ng Athirah Bakhtiar |
| author_facet | Jia Jing Lee Khuen Yen Ng Athirah Bakhtiar |
| author_sort | Jia Jing Lee |
| collection | DOAJ |
| description | Abstract The extracellular matrix (ECM) plays a critical role in cancer progression by influencing tumor growth, invasion, and metastasis. This review explores the emerging therapeutic strategies that target the ECM as a novel approach in cancer treatment. By disrupting the structural and biochemical interactions within the tumor microenvironment, ECM-targeted therapies aim to inhibit cancer progression and overcome therapeutic resistance. We examine the current state of ECM research, focusing on key components such as collagen, laminin, fibronectin, periostin, and hyaluronic acid, and their roles in tumor biology. Additionally, we discuss the challenges associated with ECM-targeted therapies, including drug delivery, specificity, and potential side effects, while highlighting recent advancements and future directions. This review underscores the potential of ECM-focused strategies to enhance the efficacy of existing treatments and contribute to more effective cancer therapies. |
| format | Article |
| id | doaj-art-857b2ad0bcba44f7af1c90a929f9b37d |
| institution | DOAJ |
| issn | 2050-7771 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj-art-857b2ad0bcba44f7af1c90a929f9b37d2025-08-20T03:16:55ZengBMCBiomarker Research2050-77712025-05-0113112510.1186/s40364-025-00757-3Extracellular matrix: unlocking new avenues in cancer treatmentJia Jing Lee0Khuen Yen Ng1Athirah Bakhtiar2School of Pharmacy, Monash University MalaysiaSchool of Pharmacy, Monash University MalaysiaSchool of Pharmacy, Monash University MalaysiaAbstract The extracellular matrix (ECM) plays a critical role in cancer progression by influencing tumor growth, invasion, and metastasis. This review explores the emerging therapeutic strategies that target the ECM as a novel approach in cancer treatment. By disrupting the structural and biochemical interactions within the tumor microenvironment, ECM-targeted therapies aim to inhibit cancer progression and overcome therapeutic resistance. We examine the current state of ECM research, focusing on key components such as collagen, laminin, fibronectin, periostin, and hyaluronic acid, and their roles in tumor biology. Additionally, we discuss the challenges associated with ECM-targeted therapies, including drug delivery, specificity, and potential side effects, while highlighting recent advancements and future directions. This review underscores the potential of ECM-focused strategies to enhance the efficacy of existing treatments and contribute to more effective cancer therapies.https://doi.org/10.1186/s40364-025-00757-3Extracellular matrixCancerCancer resistanceTumor microenvironment |
| spellingShingle | Jia Jing Lee Khuen Yen Ng Athirah Bakhtiar Extracellular matrix: unlocking new avenues in cancer treatment Biomarker Research Extracellular matrix Cancer Cancer resistance Tumor microenvironment |
| title | Extracellular matrix: unlocking new avenues in cancer treatment |
| title_full | Extracellular matrix: unlocking new avenues in cancer treatment |
| title_fullStr | Extracellular matrix: unlocking new avenues in cancer treatment |
| title_full_unstemmed | Extracellular matrix: unlocking new avenues in cancer treatment |
| title_short | Extracellular matrix: unlocking new avenues in cancer treatment |
| title_sort | extracellular matrix unlocking new avenues in cancer treatment |
| topic | Extracellular matrix Cancer Cancer resistance Tumor microenvironment |
| url | https://doi.org/10.1186/s40364-025-00757-3 |
| work_keys_str_mv | AT jiajinglee extracellularmatrixunlockingnewavenuesincancertreatment AT khuenyenng extracellularmatrixunlockingnewavenuesincancertreatment AT athirahbakhtiar extracellularmatrixunlockingnewavenuesincancertreatment |