Carbonyl reductase 4 suppresses colorectal cancer progression through the DNMT3B/CBR4/FASN/mTOR axis

Carbonyl reductase 4 suppresses colorectal cancer progression through the DNMT3B/CBR4/FASN/mTOR axis

Abstract Lipid metabolism is implicated in the initiation and progression of human colorectal cancer (CRC). Carbonyl reductase 4 (CBR4), a member of the carbonyl reductase family, plays a role in the biosynthesis of fatty acids. However, its involvement in CRC remains poorly understood. In this stud...

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Bibliographic Details
Main Authors: Jingjing Zhang, Tiaotiao Chen, Wencheng Wu, Chunhua Hu, Bangting Wang, Xiaofeng Jia, Mujie Ye
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cancer Cell International
Subjects:
Colorectal cancer
CBR4
FASN
DNA methylation
mTOR
Online Access:https://doi.org/10.1186/s12935-025-03776-0
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