Development and Validation of a New Immune-Inflammatory-Nutritional Score to Predict Pathological Complete Response in Triple-Negative Breast Cancer Undergoing Neoadjuvant Chemotherapy: A Two-Center Study
Shuai Wang,1,* Yuting Song,2,* Jiajun Ding,1 Mengxuan Li,1 Yidi Wang,1 Yujie Bai,1 Haoyi Zi,1 Jianing Sun,1 Cong Fan,1 He Chen,1 Ting Luo,2 Ting Wang1 1Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, Peo...
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Dove Medical Press
2025-07-01
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| Series: | Journal of Inflammation Research |
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| author | Wang S Song Y Ding J Li M Wang Y Bai Y Zi H Sun J Fan C Chen H Luo T Wang T |
| author_facet | Wang S Song Y Ding J Li M Wang Y Bai Y Zi H Sun J Fan C Chen H Luo T Wang T |
| author_sort | Wang S |
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| description | Shuai Wang,1,* Yuting Song,2,* Jiajun Ding,1 Mengxuan Li,1 Yidi Wang,1 Yujie Bai,1 Haoyi Zi,1 Jianing Sun,1 Cong Fan,1 He Chen,1 Ting Luo,2 Ting Wang1 1Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, People’s Republic of China; 2Institute of Breast Health Medicine, Department of Medical Oncology, Cancer Center, Breast Center, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ting Wang, Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, No. 127, Changle West Road, Xi’an, Shaanxi, 710032, People’s Republic of China, Email ting_w100@126.com Ting Luo, Institute of Breast Health Medicine, Department of Medical Oncology, Cancer Center, Breast Center, West China Hospital, Sichuan University, 37 Guoxue Alley, Wuhou District, Chengdu, Sichuan, 610000, People’s Republic of China, Email luoting@wchscu.cnPurpose: To construct a novel immune-inflammatory-nutritional (IIN) score based on peripheral blood biomarkers related to inflammation, immunity, and nutrition, and to predict the efficacy of neoadjuvant chemotherapy (NAC) in patients with triple-negative breast cancer (TNBC).Patients and Methods: We retrospectively selected 431 patients with TNBC from Xijing Hospital, and then randomly divided the patients into a training set and an internal validation set in a ratio of 7:3. An external validation set was included with 154 patients selected from West China Hospital of Sichuan University. In the training set, patients were divided into the pathological complete response (pCR) group and the non-pathological complete response group. Univariate logistic regression analysis and LASSO regression analysis were used to select biomarkers that affect the efficacy of NAC in TNBC patients and to construct the IIN score. A nomogram model was constructed based on the IIN score and clinical pathological characteristics to predict whether TNBC patients could achieve pCR after NAC before treatment. The predictive performance and clinical application value of the nomogram model were assessed using the receiver operating characteristic (ROC) curve, calibration curve, decision curve analysis, and confusion matrix.Results: Through LASSO regression analysis, 6 biomarkers were ultimately identified to construct the scoring system. A nomogram model was constructed based on the IIN score and clinical pathological characteristics, and the ROC curve showed the areas under the curve to be 0.827, 0.786, and 0.754 in the training set, internal validation set, and external validation set, respectively. Calibration curves, decision curves, and confusion matrices all demonstrated that the nomogram model exhibited robust predictive performance and holds certain clinical application value.Conclusion: The nomogram model based on the IIN score offers high predictive performance and can accurately predict the efficacy of NAC in TNBC patients before treatment, highlighting its clinical application potential.Keywords: triple-negative breast cancer, immune-inflammatory-nutritional score, pathological complete response, neoadjuvant chemotherapy, nomogram |
| format | Article |
| id | doaj-art-85757b17d6f44649b1b002902195dfd6 |
| institution | Kabale University |
| issn | 1178-7031 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj-art-85757b17d6f44649b1b002902195dfd62025-08-20T03:30:33ZengDove Medical PressJournal of Inflammation Research1178-70312025-07-01Volume 18Issue 193659378104884Development and Validation of a New Immune-Inflammatory-Nutritional Score to Predict Pathological Complete Response in Triple-Negative Breast Cancer Undergoing Neoadjuvant Chemotherapy: A Two-Center StudyWang S0Song Y1Ding J2Li M3Wang Y4Bai Y5Zi H6Sun J7Fan C8Chen H9Luo T10Wang T11Department of Thyroid, Breast and Vascular SurgeryDepartment of Medical Oncology, Breast CenterDepartment of Thyroid, Breast and Vascular SurgeryDepartment of Thyroid, Breast and Vascular SurgeryDepartment of Thyroid, Breast and Vascular SurgeryDepartment of Thyroid, Breast and Vascular SurgeryDepartment of Thyroid, Breast and Vascular SurgeryDepartment of Thyroid, Breast and Vascular SurgeryDepartment of Thyroid, Breast and Vascular SurgeryDepartment of Thyroid, Breast and Vascular SurgeryDepartment of Medical OncologyDepartment of Thyroid, Breast and Vascular SurgeryShuai Wang,1,* Yuting Song,2,* Jiajun Ding,1 Mengxuan Li,1 Yidi Wang,1 Yujie Bai,1 Haoyi Zi,1 Jianing Sun,1 Cong Fan,1 He Chen,1 Ting Luo,2 Ting Wang1 1Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, People’s Republic of China; 2Institute of Breast Health Medicine, Department of Medical Oncology, Cancer Center, Breast Center, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ting Wang, Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, No. 127, Changle West Road, Xi’an, Shaanxi, 710032, People’s Republic of China, Email ting_w100@126.com Ting Luo, Institute of Breast Health Medicine, Department of Medical Oncology, Cancer Center, Breast Center, West China Hospital, Sichuan University, 37 Guoxue Alley, Wuhou District, Chengdu, Sichuan, 610000, People’s Republic of China, Email luoting@wchscu.cnPurpose: To construct a novel immune-inflammatory-nutritional (IIN) score based on peripheral blood biomarkers related to inflammation, immunity, and nutrition, and to predict the efficacy of neoadjuvant chemotherapy (NAC) in patients with triple-negative breast cancer (TNBC).Patients and Methods: We retrospectively selected 431 patients with TNBC from Xijing Hospital, and then randomly divided the patients into a training set and an internal validation set in a ratio of 7:3. An external validation set was included with 154 patients selected from West China Hospital of Sichuan University. In the training set, patients were divided into the pathological complete response (pCR) group and the non-pathological complete response group. Univariate logistic regression analysis and LASSO regression analysis were used to select biomarkers that affect the efficacy of NAC in TNBC patients and to construct the IIN score. A nomogram model was constructed based on the IIN score and clinical pathological characteristics to predict whether TNBC patients could achieve pCR after NAC before treatment. The predictive performance and clinical application value of the nomogram model were assessed using the receiver operating characteristic (ROC) curve, calibration curve, decision curve analysis, and confusion matrix.Results: Through LASSO regression analysis, 6 biomarkers were ultimately identified to construct the scoring system. A nomogram model was constructed based on the IIN score and clinical pathological characteristics, and the ROC curve showed the areas under the curve to be 0.827, 0.786, and 0.754 in the training set, internal validation set, and external validation set, respectively. Calibration curves, decision curves, and confusion matrices all demonstrated that the nomogram model exhibited robust predictive performance and holds certain clinical application value.Conclusion: The nomogram model based on the IIN score offers high predictive performance and can accurately predict the efficacy of NAC in TNBC patients before treatment, highlighting its clinical application potential.Keywords: triple-negative breast cancer, immune-inflammatory-nutritional score, pathological complete response, neoadjuvant chemotherapy, nomogramhttps://www.dovepress.com/development-and-validation-of-a-new-immune-inflammatory-nutritional-sc-peer-reviewed-fulltext-article-JIRtriple-negative breast cancerimmune-inflammatory-nutritional scorepathological complete responseneoadjuvant chemotherapynomogram |
| spellingShingle | Wang S Song Y Ding J Li M Wang Y Bai Y Zi H Sun J Fan C Chen H Luo T Wang T Development and Validation of a New Immune-Inflammatory-Nutritional Score to Predict Pathological Complete Response in Triple-Negative Breast Cancer Undergoing Neoadjuvant Chemotherapy: A Two-Center Study Journal of Inflammation Research triple-negative breast cancer immune-inflammatory-nutritional score pathological complete response neoadjuvant chemotherapy nomogram |
| title | Development and Validation of a New Immune-Inflammatory-Nutritional Score to Predict Pathological Complete Response in Triple-Negative Breast Cancer Undergoing Neoadjuvant Chemotherapy: A Two-Center Study |
| title_full | Development and Validation of a New Immune-Inflammatory-Nutritional Score to Predict Pathological Complete Response in Triple-Negative Breast Cancer Undergoing Neoadjuvant Chemotherapy: A Two-Center Study |
| title_fullStr | Development and Validation of a New Immune-Inflammatory-Nutritional Score to Predict Pathological Complete Response in Triple-Negative Breast Cancer Undergoing Neoadjuvant Chemotherapy: A Two-Center Study |
| title_full_unstemmed | Development and Validation of a New Immune-Inflammatory-Nutritional Score to Predict Pathological Complete Response in Triple-Negative Breast Cancer Undergoing Neoadjuvant Chemotherapy: A Two-Center Study |
| title_short | Development and Validation of a New Immune-Inflammatory-Nutritional Score to Predict Pathological Complete Response in Triple-Negative Breast Cancer Undergoing Neoadjuvant Chemotherapy: A Two-Center Study |
| title_sort | development and validation of a new immune inflammatory nutritional score to predict pathological complete response in triple negative breast cancer undergoing neoadjuvant chemotherapy a two center study |
| topic | triple-negative breast cancer immune-inflammatory-nutritional score pathological complete response neoadjuvant chemotherapy nomogram |
| url | https://www.dovepress.com/development-and-validation-of-a-new-immune-inflammatory-nutritional-sc-peer-reviewed-fulltext-article-JIR |
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