Jurkat T-cell lines exhibit marked genomic instability affecting karyotype, mutational profile, gene expression, immunophenotype and function

Jurkat T-cell lines exhibit marked genomic instability affecting karyotype, mutational profile, gene expression, immunophenotype and function

Abstract The Jurkat cell line, derived from a case of T-cell lymphoblastic leukaemia, is widely employed as a model T-cell for biomedical research, including for the preclinical characterisation of cellular therapies such as chimeric antigen receptor T-cells. Here, we characterised genomic, transcri...

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Bibliographic Details
Main Authors: Andrew Wilson, Nathaniel Dasyam, Felix O’Hagan, Dianna Farrell, Claire Turner, Anne Jay, Alfonso Schmidt, Rachel Beddow, Tina Lillis, Tom Chin, Rachel Perret, Michelle McCulley, Robert Weinkove
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-95903-0
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