CD22-targeted chimeric antigen receptor-modified T cells for children and adults with relapse of B-cell acute lymphoblastic leukemia after CD19-directed immunotherapy

CD22-targeted chimeric antigen receptor-modified T cells for children and adults with relapse of B-cell acute lymphoblastic leukemia after CD19-directed immunotherapy

Background Relapse of B-cell acute lymphoblastic leukemia (B-ALL) with CD19-antigen loss after CD19-targeted chimeric antigen receptor (CAR) T-cell therapy has a dismal prognosis. Novel immunotherapeutic strategies for this patient population are urgently needed.Methods We tested a novel, fully huma...

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Main Authors: Clare Taylor, Carl H June, Joseph A Fraietta, Boris Engels, Gabriela Plesa, Marco Ruella, Stephan A Grupp, Hongyan Liu, Colleen Callahan, Shannon L Maude, Regina M Myers, Caroline Diorio, Yimei Li, Vanessa Gonzalez, Julie K Jadlowsky, Amanda M DiNofia, Gerald Wertheim, Donald L Siegel, Emma Iannone, Laura Shinehouse, Jennifer L Brogdon, Elizabeth O Hexner, Diane Baniewicz, Richard Aplenc, Allison Barz Leahy, Susan E McClory, Susan R Rheingold, Lisa Wray, Noelle V Frey
Format: Article
Language:English
Published: BMJ Publishing Group 2025-04-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/4/e011549.full
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