Antitumor Effects of Quercetin and Luteolin in A375 Cutaneous Melanoma Cell Line Are Mediated by Upregulation of P-ERK, c-Myc, and the Upstream GPER

Antitumor Effects of Quercetin and Luteolin in A375 Cutaneous Melanoma Cell Line Are Mediated by Upregulation of P-ERK, c-Myc, and the Upstream GPER

Cutaneous melanoma (CM) is the most aggressive and fatal malignancy among other skin cancers and its incidence has risen steadily recently around the world. Hormone-related therapy, particularly estrogen (E2) has been used as a prospective strategy for CM treatment. Quercetin and luteolin are flavon...

Full description

Saved in:
Bibliographic Details
Main Authors: Shaymaa A. Hussein, Nidaa A. Ababneh, Noor Tarawneh, Mohammad A. Ismail, Abdalla Awidi, Shtaywy Abdalla
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Life
Subjects:
cutaneous melanoma
G-protein coupled estrogen receptor
GPER agonist
GPER antagonist
luteolin
quercetin
Online Access:https://www.mdpi.com/2075-1729/15/3/417
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items