Herbal Compounds Play a Role in Neuroprotection through the Inhibition of Microglial Activation
Since microglia possess both neuroprotective and neurotoxic potential, they play a crucial role in the central nervous system (CNS). Excessive microglial activation induces inflammation-mediated neuronal damage and degeneration. At present, numerous herbal compounds are able to suppress neurotoxicit...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/9348046 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850214446268416000 |
|---|---|
| author | Yan Fu Jianmei Yang Xingyu Wang Pin Yang Yang Zhao Kun Li Yongjun Chen Ying Xu |
| author_facet | Yan Fu Jianmei Yang Xingyu Wang Pin Yang Yang Zhao Kun Li Yongjun Chen Ying Xu |
| author_sort | Yan Fu |
| collection | DOAJ |
| description | Since microglia possess both neuroprotective and neurotoxic potential, they play a crucial role in the central nervous system (CNS). Excessive microglial activation induces inflammation-mediated neuronal damage and degeneration. At present, numerous herbal compounds are able to suppress neurotoxicity via inhibiting microglial activation. Therefore, many researchers focus on pharmacological inhibitors of microglial activation to ameliorate neurodegenerative disorders. Further work should concentrate on the exploration of new herbal compounds, which characteristically inhibit microglial neurotoxicity, rather than modulating neuroprotection alone. In this review, we summarize these herbal compounds, which in the past several years have been shown to exert potential neuroprotective activity by inhibiting microglial activation. The therapeutic targets and pharmacological mechanisms of these compounds have also been discussed. |
| format | Article |
| id | doaj-art-856b477cb0ed4cbdb4dc13a787580c91 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-856b477cb0ed4cbdb4dc13a787580c912025-08-20T02:08:54ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/93480469348046Herbal Compounds Play a Role in Neuroprotection through the Inhibition of Microglial ActivationYan Fu0Jianmei Yang1Xingyu Wang2Pin Yang3Yang Zhao4Kun Li5Yongjun Chen6Ying Xu7Department of Physiology, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, ChinaXuhui District Central Hospital, Shanghai 200031, ChinaDepartment of Physiology, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, ChinaDepartment of Physiology, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, ChinaDepartment of Physiology, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, ChinaDepartment of Physiology, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, ChinaSouth China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, 232 Waihuan Dong Road, Guangzhou 510006, ChinaDepartment of Physiology, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, ChinaSince microglia possess both neuroprotective and neurotoxic potential, they play a crucial role in the central nervous system (CNS). Excessive microglial activation induces inflammation-mediated neuronal damage and degeneration. At present, numerous herbal compounds are able to suppress neurotoxicity via inhibiting microglial activation. Therefore, many researchers focus on pharmacological inhibitors of microglial activation to ameliorate neurodegenerative disorders. Further work should concentrate on the exploration of new herbal compounds, which characteristically inhibit microglial neurotoxicity, rather than modulating neuroprotection alone. In this review, we summarize these herbal compounds, which in the past several years have been shown to exert potential neuroprotective activity by inhibiting microglial activation. The therapeutic targets and pharmacological mechanisms of these compounds have also been discussed.http://dx.doi.org/10.1155/2018/9348046 |
| spellingShingle | Yan Fu Jianmei Yang Xingyu Wang Pin Yang Yang Zhao Kun Li Yongjun Chen Ying Xu Herbal Compounds Play a Role in Neuroprotection through the Inhibition of Microglial Activation Journal of Immunology Research |
| title | Herbal Compounds Play a Role in Neuroprotection through the Inhibition of Microglial Activation |
| title_full | Herbal Compounds Play a Role in Neuroprotection through the Inhibition of Microglial Activation |
| title_fullStr | Herbal Compounds Play a Role in Neuroprotection through the Inhibition of Microglial Activation |
| title_full_unstemmed | Herbal Compounds Play a Role in Neuroprotection through the Inhibition of Microglial Activation |
| title_short | Herbal Compounds Play a Role in Neuroprotection through the Inhibition of Microglial Activation |
| title_sort | herbal compounds play a role in neuroprotection through the inhibition of microglial activation |
| url | http://dx.doi.org/10.1155/2018/9348046 |
| work_keys_str_mv | AT yanfu herbalcompoundsplayaroleinneuroprotectionthroughtheinhibitionofmicroglialactivation AT jianmeiyang herbalcompoundsplayaroleinneuroprotectionthroughtheinhibitionofmicroglialactivation AT xingyuwang herbalcompoundsplayaroleinneuroprotectionthroughtheinhibitionofmicroglialactivation AT pinyang herbalcompoundsplayaroleinneuroprotectionthroughtheinhibitionofmicroglialactivation AT yangzhao herbalcompoundsplayaroleinneuroprotectionthroughtheinhibitionofmicroglialactivation AT kunli herbalcompoundsplayaroleinneuroprotectionthroughtheinhibitionofmicroglialactivation AT yongjunchen herbalcompoundsplayaroleinneuroprotectionthroughtheinhibitionofmicroglialactivation AT yingxu herbalcompoundsplayaroleinneuroprotectionthroughtheinhibitionofmicroglialactivation |