Differential activity of MAPK signalling defines fibroblast subtypes in pancreatic cancer

Differential activity of MAPK signalling defines fibroblast subtypes in pancreatic cancer

Abstract Fibroblast heterogeneity is increasingly recognised across cancer conditions. Given their important contribution to disease progression, mapping fibroblasts’ heterogeneity is critical to devise effective anti-cancer therapies. Cancer-associated fibroblasts (CAFs) represent the most abundant...

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Main Authors: Lisa Veghini, Davide Pasini, Rui Fang, Pietro Delfino, Dea Filippini, Christian Neander, Caterina Vicentini, Elena Fiorini, Francesca Lupo, Sabrina L. D’Agosto, Carmine Carbone, Antonio Agostini, Geny Piro, Diego Rosa, Michele Bevere, Peter Markus, Diana Behrens, Claudio Luchini, Rita T. Lawlor, Aldo Scarpa, Giulia Biffi, Phyllis F. Cheung, Jens T. Siveke, Vincenzo Corbo
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54975-8
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