Genome-Wide Association of Heroin Dependence in Han Chinese.
Drug addiction is a costly and recurring healthcare problem, necessitating a need to understand risk factors and mechanisms of addiction, and to identify new biomarkers. To date, genome-wide association studies (GWAS) for heroin addiction have been limited; moreover they have been restricted to exam...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0167388&type=printable |
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| author | Gursharan Kalsi Jack Euesden Jonathan R I Coleman Francesca Ducci Fazil Aliev Stephen J Newhouse Xiehe Liu Xiaohong Ma Yingcheng Wang David A Collier Philip Asherson Tao Li Gerome Breen |
| author_facet | Gursharan Kalsi Jack Euesden Jonathan R I Coleman Francesca Ducci Fazil Aliev Stephen J Newhouse Xiehe Liu Xiaohong Ma Yingcheng Wang David A Collier Philip Asherson Tao Li Gerome Breen |
| author_sort | Gursharan Kalsi |
| collection | DOAJ |
| description | Drug addiction is a costly and recurring healthcare problem, necessitating a need to understand risk factors and mechanisms of addiction, and to identify new biomarkers. To date, genome-wide association studies (GWAS) for heroin addiction have been limited; moreover they have been restricted to examining samples of European and African-American origin due to difficulty of recruiting samples from other populations. This is the first study to test a Han Chinese population; we performed a GWAS on a homogeneous sample of 370 Han Chinese subjects diagnosed with heroin dependence using the DSM-IV criteria and 134 ethnically matched controls. Analysis using the diagnostic criteria of heroin dependence yielded suggestive evidence for association between variants in the genes CCDC42 (coiled coil domain 42; p = 2.8x10-7) and BRSK2 (BR serine/threonine 2; p = 4.110-6). In addition, we found evidence for risk variants within the ARHGEF10 (Rho guanine nucleotide exchange factor 10) gene on chromosome 8 and variants in a region on chromosome 20q13, which is gene-poor but has a concentration of mRNAs and predicted miRNAs. Gene-based association analysis identified genome-wide significant association between variants in CCDC42 and heroin addiction. Additionally, when we investigated shared risk variants between heroin addiction and risk of other addiction-related and psychiatric phenotypes using polygenic risk scores, we found a suggestive relationship with variants predicting tobacco addiction, and a significant relationship with variants predicting schizophrenia. Our genome wide association study of heroin dependence provides data in a novel sample, with functionally plausible results and evidence of genetic data of value to the field. |
| format | Article |
| id | doaj-art-855ad098b111430ea8d8e6b8934abb3c |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-855ad098b111430ea8d8e6b8934abb3c2025-08-20T02:03:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011112e016738810.1371/journal.pone.0167388Genome-Wide Association of Heroin Dependence in Han Chinese.Gursharan KalsiJack EuesdenJonathan R I ColemanFrancesca DucciFazil AlievStephen J NewhouseXiehe LiuXiaohong MaYingcheng WangDavid A CollierPhilip AshersonTao LiGerome BreenDrug addiction is a costly and recurring healthcare problem, necessitating a need to understand risk factors and mechanisms of addiction, and to identify new biomarkers. To date, genome-wide association studies (GWAS) for heroin addiction have been limited; moreover they have been restricted to examining samples of European and African-American origin due to difficulty of recruiting samples from other populations. This is the first study to test a Han Chinese population; we performed a GWAS on a homogeneous sample of 370 Han Chinese subjects diagnosed with heroin dependence using the DSM-IV criteria and 134 ethnically matched controls. Analysis using the diagnostic criteria of heroin dependence yielded suggestive evidence for association between variants in the genes CCDC42 (coiled coil domain 42; p = 2.8x10-7) and BRSK2 (BR serine/threonine 2; p = 4.110-6). In addition, we found evidence for risk variants within the ARHGEF10 (Rho guanine nucleotide exchange factor 10) gene on chromosome 8 and variants in a region on chromosome 20q13, which is gene-poor but has a concentration of mRNAs and predicted miRNAs. Gene-based association analysis identified genome-wide significant association between variants in CCDC42 and heroin addiction. Additionally, when we investigated shared risk variants between heroin addiction and risk of other addiction-related and psychiatric phenotypes using polygenic risk scores, we found a suggestive relationship with variants predicting tobacco addiction, and a significant relationship with variants predicting schizophrenia. Our genome wide association study of heroin dependence provides data in a novel sample, with functionally plausible results and evidence of genetic data of value to the field.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0167388&type=printable |
| spellingShingle | Gursharan Kalsi Jack Euesden Jonathan R I Coleman Francesca Ducci Fazil Aliev Stephen J Newhouse Xiehe Liu Xiaohong Ma Yingcheng Wang David A Collier Philip Asherson Tao Li Gerome Breen Genome-Wide Association of Heroin Dependence in Han Chinese. PLoS ONE |
| title | Genome-Wide Association of Heroin Dependence in Han Chinese. |
| title_full | Genome-Wide Association of Heroin Dependence in Han Chinese. |
| title_fullStr | Genome-Wide Association of Heroin Dependence in Han Chinese. |
| title_full_unstemmed | Genome-Wide Association of Heroin Dependence in Han Chinese. |
| title_short | Genome-Wide Association of Heroin Dependence in Han Chinese. |
| title_sort | genome wide association of heroin dependence in han chinese |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0167388&type=printable |
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