Marine Resources Gels as Main Ingredient for Wound Healing Biomaterials: Obtaining and Characterization
The skin, known as the largest organ of the body, is essential for maintaining physiological balance and acts as a barrier against the external environment. When skin becomes damaged and wounds appear on the skin’s surface, a complex healing process, involving multiple types of cells and microenviro...
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MDPI AG
2024-11-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/10/11/729 |
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| author | Alina Elena Coman Maria Minodora Marin Ana Maria Roșca Madalina Georgiana Albu Kaya Rodica Roxana Constantinescu Irina Titorencu |
| author_facet | Alina Elena Coman Maria Minodora Marin Ana Maria Roșca Madalina Georgiana Albu Kaya Rodica Roxana Constantinescu Irina Titorencu |
| author_sort | Alina Elena Coman |
| collection | DOAJ |
| description | The skin, known as the largest organ of the body, is essential for maintaining physiological balance and acts as a barrier against the external environment. When skin becomes damaged and wounds appear on the skin’s surface, a complex healing process, involving multiple types of cells and microenvironments, take place. Selecting a suitable dressing for a wound is crucial for accelerating healing, reducing treatment costs, and improving the patient’s overall health. Starting from natural resources such as perch skin (<i>P. fluviatilis</i>), this article aims to develop biocompatible materials for regenerative medicine from collagen in the form of gels/gelatines. The extracted gels were physical/chemical and structurally analyzed. In order to obtain collagen scaffolds for wound healing, the extracted collagen gels from perch skin were further freeze-dried. The ability of these scaffolds is essential for controlling moisture levels during wound healing; therefore, it was necessary to investigate the samples’ ability to absorb water. The assessed collagen-based scaffolds were microbiologically tested, and their biocompatibility was investigated by incubating human adult dermal fibroblasts. The outcomes reveal an innovative path for the production of biomaterials used in wound healing, starting from collagen derived from marine sources. |
| format | Article |
| id | doaj-art-8559cd12f8d54480967d8f3ce9bc1b8a |
| institution | OA Journals |
| issn | 2310-2861 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj-art-8559cd12f8d54480967d8f3ce9bc1b8a2025-08-20T01:53:53ZengMDPI AGGels2310-28612024-11-01101172910.3390/gels10110729Marine Resources Gels as Main Ingredient for Wound Healing Biomaterials: Obtaining and CharacterizationAlina Elena Coman0Maria Minodora Marin1Ana Maria Roșca2Madalina Georgiana Albu Kaya3Rodica Roxana Constantinescu4Irina Titorencu5Department of Collagen, Division of Leather and Footwear Research Institute, National Research and Development Institute for Textiles and Leather, 93 Ion Minulescu Str., 031215 Bucharest, RomaniaAdvanced Polymer Materials Group, University POLITEHNICA of Bucharest, 1-7 Polizu Street, 011061 Bucharest, RomaniaInstitute of Cellular Biology and Pathology ‘’Nicolae Simionescu’’, 8 B. P. Hasdeu Street, District 5, 050568 Bucharest, RomaniaDepartment of Collagen, Division of Leather and Footwear Research Institute, National Research and Development Institute for Textiles and Leather, 93 Ion Minulescu Str., 031215 Bucharest, RomaniaDepartment of Collagen, Division of Leather and Footwear Research Institute, National Research and Development Institute for Textiles and Leather, 93 Ion Minulescu Str., 031215 Bucharest, RomaniaInstitute of Cellular Biology and Pathology ‘’Nicolae Simionescu’’, 8 B. P. Hasdeu Street, District 5, 050568 Bucharest, RomaniaThe skin, known as the largest organ of the body, is essential for maintaining physiological balance and acts as a barrier against the external environment. When skin becomes damaged and wounds appear on the skin’s surface, a complex healing process, involving multiple types of cells and microenvironments, take place. Selecting a suitable dressing for a wound is crucial for accelerating healing, reducing treatment costs, and improving the patient’s overall health. Starting from natural resources such as perch skin (<i>P. fluviatilis</i>), this article aims to develop biocompatible materials for regenerative medicine from collagen in the form of gels/gelatines. The extracted gels were physical/chemical and structurally analyzed. In order to obtain collagen scaffolds for wound healing, the extracted collagen gels from perch skin were further freeze-dried. The ability of these scaffolds is essential for controlling moisture levels during wound healing; therefore, it was necessary to investigate the samples’ ability to absorb water. The assessed collagen-based scaffolds were microbiologically tested, and their biocompatibility was investigated by incubating human adult dermal fibroblasts. The outcomes reveal an innovative path for the production of biomaterials used in wound healing, starting from collagen derived from marine sources.https://www.mdpi.com/2310-2861/10/11/729fish wastesmarine collagenbiomaterialswound healing |
| spellingShingle | Alina Elena Coman Maria Minodora Marin Ana Maria Roșca Madalina Georgiana Albu Kaya Rodica Roxana Constantinescu Irina Titorencu Marine Resources Gels as Main Ingredient for Wound Healing Biomaterials: Obtaining and Characterization Gels fish wastes marine collagen biomaterials wound healing |
| title | Marine Resources Gels as Main Ingredient for Wound Healing Biomaterials: Obtaining and Characterization |
| title_full | Marine Resources Gels as Main Ingredient for Wound Healing Biomaterials: Obtaining and Characterization |
| title_fullStr | Marine Resources Gels as Main Ingredient for Wound Healing Biomaterials: Obtaining and Characterization |
| title_full_unstemmed | Marine Resources Gels as Main Ingredient for Wound Healing Biomaterials: Obtaining and Characterization |
| title_short | Marine Resources Gels as Main Ingredient for Wound Healing Biomaterials: Obtaining and Characterization |
| title_sort | marine resources gels as main ingredient for wound healing biomaterials obtaining and characterization |
| topic | fish wastes marine collagen biomaterials wound healing |
| url | https://www.mdpi.com/2310-2861/10/11/729 |
| work_keys_str_mv | AT alinaelenacoman marineresourcesgelsasmainingredientforwoundhealingbiomaterialsobtainingandcharacterization AT mariaminodoramarin marineresourcesgelsasmainingredientforwoundhealingbiomaterialsobtainingandcharacterization AT anamariarosca marineresourcesgelsasmainingredientforwoundhealingbiomaterialsobtainingandcharacterization AT madalinageorgianaalbukaya marineresourcesgelsasmainingredientforwoundhealingbiomaterialsobtainingandcharacterization AT rodicaroxanaconstantinescu marineresourcesgelsasmainingredientforwoundhealingbiomaterialsobtainingandcharacterization AT irinatitorencu marineresourcesgelsasmainingredientforwoundhealingbiomaterialsobtainingandcharacterization |