Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients
Diabetic kidney disease develops in half of genetically predisposed patients with type 2 diabetes (T2DM). Early diagnosis of kidney damage and nephroprotective treatment are the ways of preventing the disease progression. Our aim was to evaluate selected laboratory markers of glomerular and tubular...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/7659243 |
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| author | Agnieszka Żyłka Paulina Dumnicka Beata Kuśnierz-Cabala Agnieszka Gala-Błądzińska Piotr Ceranowicz Jakub Kucharz Anna Ząbek-Adamska Barbara Maziarz Ryszard Drożdż Marek Kuźniewski |
| author_facet | Agnieszka Żyłka Paulina Dumnicka Beata Kuśnierz-Cabala Agnieszka Gala-Błądzińska Piotr Ceranowicz Jakub Kucharz Anna Ząbek-Adamska Barbara Maziarz Ryszard Drożdż Marek Kuźniewski |
| author_sort | Agnieszka Żyłka |
| collection | DOAJ |
| description | Diabetic kidney disease develops in half of genetically predisposed patients with type 2 diabetes (T2DM). Early diagnosis of kidney damage and nephroprotective treatment are the ways of preventing the disease progression. Our aim was to evaluate selected laboratory markers of glomerular and tubular damage in T2DM patients with early stages of chronic kidney disease (G1/G2, A1/A2) for their associations with A2 albuminuria and early decline in the estimated glomerular filtration rate (eGFR). Among 80 T2DM patients with median eGFR of 92.4 ml/min/1.73 m2 and median urinary albumin to creatinine ratio (uACR) of 4.69 mg/g, 19 had uACR > 30 mg/g (A2). Higher serum cystatin C, serum and urine neutrophil gelatinase associated lipocalin (NGAL), urine kidney injury molecule 1 (KIM-1), detectable urine transferrin and IgG, and lower serum uromodulin significantly predicted A2 albuminuria, urine KIM-1/creatinine ratio, and IgG being the best predictors. Albuminuria, urine NGAL/creatinine, and IgG correlated with diabetes duration. Albuminuria, urine NGAL, transferrin, IgG, and uromodulin correlated with diabetes control. In a subgroup of 29 patients, retrospective data were available on changes in eGFR and uACR over one year. Decline in eGFR was observed in 17 patients and increase in uACR in 10 patients. Serum and urine NGAL correlated with eGFR changes. Higher urine NGAL, KIM-1/creatinine ratio, and detectable IgG were significantly associated with the increase in uACR. Widely available markers, serum cystatin C, urine IgG, transferrin, and NGAL, may help in early assessment of kidney disease in T2DM patients; however, large prospective studies are needed to confirm the conclusion. |
| format | Article |
| id | doaj-art-854aeb97a35c4164b615807ecc98a819 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-854aeb97a35c4164b615807ecc98a8192025-02-03T05:51:18ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/76592437659243Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic PatientsAgnieszka Żyłka0Paulina Dumnicka1Beata Kuśnierz-Cabala2Agnieszka Gala-Błądzińska3Piotr Ceranowicz4Jakub Kucharz5Anna Ząbek-Adamska6Barbara Maziarz7Ryszard Drożdż8Marek Kuźniewski9St. Queen Jadwiga Clinical District Hospital No. 2, 35-301 Rzeszów, PolandDepartment of Medical Diagnostics, Jagiellonian University Medical College, 30-688 Kraków, PolandDepartment of Diagnostics, Chair of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Kraków, PolandSt. Queen Jadwiga Clinical District Hospital No. 2, 35-301 Rzeszów, PolandDepartment of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Kraków, PolandDepartment of Uro-Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, PolandDiagnostic Department, University Hospital, 31-501 Kraków, PolandDepartment of Diagnostics, Chair of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Kraków, PolandDepartment of Medical Diagnostics, Jagiellonian University Medical College, 30-688 Kraków, PolandChair and Department of Nephrology, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Kraków, PolandDiabetic kidney disease develops in half of genetically predisposed patients with type 2 diabetes (T2DM). Early diagnosis of kidney damage and nephroprotective treatment are the ways of preventing the disease progression. Our aim was to evaluate selected laboratory markers of glomerular and tubular damage in T2DM patients with early stages of chronic kidney disease (G1/G2, A1/A2) for their associations with A2 albuminuria and early decline in the estimated glomerular filtration rate (eGFR). Among 80 T2DM patients with median eGFR of 92.4 ml/min/1.73 m2 and median urinary albumin to creatinine ratio (uACR) of 4.69 mg/g, 19 had uACR > 30 mg/g (A2). Higher serum cystatin C, serum and urine neutrophil gelatinase associated lipocalin (NGAL), urine kidney injury molecule 1 (KIM-1), detectable urine transferrin and IgG, and lower serum uromodulin significantly predicted A2 albuminuria, urine KIM-1/creatinine ratio, and IgG being the best predictors. Albuminuria, urine NGAL/creatinine, and IgG correlated with diabetes duration. Albuminuria, urine NGAL, transferrin, IgG, and uromodulin correlated with diabetes control. In a subgroup of 29 patients, retrospective data were available on changes in eGFR and uACR over one year. Decline in eGFR was observed in 17 patients and increase in uACR in 10 patients. Serum and urine NGAL correlated with eGFR changes. Higher urine NGAL, KIM-1/creatinine ratio, and detectable IgG were significantly associated with the increase in uACR. Widely available markers, serum cystatin C, urine IgG, transferrin, and NGAL, may help in early assessment of kidney disease in T2DM patients; however, large prospective studies are needed to confirm the conclusion.http://dx.doi.org/10.1155/2018/7659243 |
| spellingShingle | Agnieszka Żyłka Paulina Dumnicka Beata Kuśnierz-Cabala Agnieszka Gala-Błądzińska Piotr Ceranowicz Jakub Kucharz Anna Ząbek-Adamska Barbara Maziarz Ryszard Drożdż Marek Kuźniewski Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients Mediators of Inflammation |
| title | Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients |
| title_full | Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients |
| title_fullStr | Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients |
| title_full_unstemmed | Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients |
| title_short | Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients |
| title_sort | markers of glomerular and tubular damage in the early stage of kidney disease in type 2 diabetic patients |
| url | http://dx.doi.org/10.1155/2018/7659243 |
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