Guanine is an inhibitor of c-jun terminal kinases

Guanine is an inhibitor of c-jun terminal kinases

Abstract The toxicity of purine bases adenine and guanine is mostly recognized when associated with inborn errors of purine metabolism such as Lesch-Nyhan syndrome, and metabolic diseases with a lifestyle component including gout. In these pathologies, the peripheral toxicity of purine bases is attr...

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Bibliographic Details
Main Authors: Jessica Treeby, Sherihan El-Sayed, Samuel Morgan, Sophie Maddock, George Taylor, Stacey Warwood, Julian Selley, David Knight, Benjamin Saer, Richard A. Bryce, Jean-Michel Fustin
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Guanine
Purine
JNK
MAPK
Lesch-Nyhan
Metabolism
Online Access:https://doi.org/10.1038/s41598-025-11617-3
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