SARS-CoV-2-specific antibody response characteristics in COVID-19 patients of different ages

SARS-CoV-2-specific antibody response characteristics in COVID-19 patients of different ages

Age has been found to be one of the main risk factors for the severity and outcome of COVID-19. However, differences in SARS-CoV-2 specific antibody responses among COVID-19 patients of different age groups remain largely unknown. In this study, we analyzed the IgG/IgM responses to 21 SARS-CoV-2 pro...

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Main Authors: Lu Linfang, Yu Siqi, Liu Min, Li Yang, Lei Qing, Lin Mingxi, Lai Danyun, Guo Shujuan, Jiang Hewei, Hou Hongyan, Zheng Yunxiao, Wang Xuening, Ma Mingliang, Zhang Bo, Chen Hong, Xue Junbiao, Zhang Hainan, Qi Huan, Sun Ziyong, Wang Feng, Fan Xionglin, Xu Zhaowei
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2022-02-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
SARS-CoV-2
protein microarray
age
humoral immunity
IgG and IgM
non-structural/accessory protein
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2022014
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Summary:Age has been found to be one of the main risk factors for the severity and outcome of COVID-19. However, differences in SARS-CoV-2 specific antibody responses among COVID-19 patients of different age groups remain largely unknown. In this study, we analyzed the IgG/IgM responses to 21 SARS-CoV-2 proteins and 197 peptides that fully cover the spike protein against 731 sera collected from 731 COVID-19 patients aged from 1 to <sc>92 years.</sc> We show that there is no overall difference in SARS-CoV-2 antibody responses in COVID-19 patients in the 4 age groups. By antibody response landscape maps, we find that the IgG response profiles of SARS-CoV-2 proteins are positively correlated with age. The S protein linear epitope map shows that the immunogenicity of the S-protein peptides is related to peptide sequence, disease severity and age of the COVID-19 patients. Furthermore, the enrichment analysis indicates that low S1 IgG responses are enriched in patients aged &lt;50 and high S1 IgG responses are enriched in mild COVID-19 patients aged &gt;60. In addition, high responses of non-structural/accessory proteins are enriched in severe COVID-19 patients aged &gt;70. These results suggest the distinct immune response of IgG/IgM to each SARS-CoV-2 protein in patients of different age, which may facilitate a deeper understanding of the immune responses in COVID-19 patients.
ISSN:1672-9145

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