In Virto Antioxidant Activities of New 4,5-Dihydro-1H,2,4-triazol-5-ones having Thiophene Ring with their Acidic Properties
Seven new 3-alkyl(aryl)-4-(2-thienymethylenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) were synthesized by the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with thiophene-2-carbaldehyde. In addition, N-acetyl derivatives of compounds 2d-2g were also prepared. The str...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/635459 |
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| author | H. Yuksek F. Islamoglu O. Gursoy Kol S. Bahceci M. Bekar M. Aksoy |
| author_facet | H. Yuksek F. Islamoglu O. Gursoy Kol S. Bahceci M. Bekar M. Aksoy |
| author_sort | H. Yuksek |
| collection | DOAJ |
| description | Seven new 3-alkyl(aryl)-4-(2-thienymethylenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) were synthesized by the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with thiophene-2-carbaldehyde. In addition, N-acetyl derivatives of compounds 2d-2g were also prepared. The structures of eleven new compounds synthesized were determined by elemental analysis as well as IR, NMR and UV spectral data. In addition, compounds 2a-g and 3a, 3b, 3d-f were also screened for their antioxidant activities and 2a-g were potentiometrically titrated with tetrabutylammonium hydroxide (TBAH) in four nonaqueous solvents (isopropyl alcohol, t-butyl alcohol, acetonitrile and N,N-dimethyl formamide). Also half-neutralization potential values and the corresponding pKa values were determined in all cases. |
| format | Article |
| id | doaj-art-85457a2135ed4b9a9e5bdd2e2c655c43 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-85457a2135ed4b9a9e5bdd2e2c655c432025-08-20T03:37:11ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-01841734174610.1155/2011/635459In Virto Antioxidant Activities of New 4,5-Dihydro-1H,2,4-triazol-5-ones having Thiophene Ring with their Acidic PropertiesH. Yuksek0F. Islamoglu1O. Gursoy Kol2S. Bahceci3M. Bekar4M. Aksoy5Department of Chemistry, Faculty of Science and Arts, Kafkas University, Kars-36100, TurkeyDepartment of Chemistry, Faculty of Science and Arts, Rize University, Rize-53100, TurkeyDepartment of Chemistry, Faculty of Science and Arts, Kafkas University, Kars-36100, TurkeyFatih Education Faculty, Karadeniz Technical University, Trabzon-61355, TurkeyFatih Education Faculty, Karadeniz Technical University, Trabzon-61355, TurkeyFatih Education Faculty, Karadeniz Technical University, Trabzon-61355, TurkeySeven new 3-alkyl(aryl)-4-(2-thienymethylenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) were synthesized by the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with thiophene-2-carbaldehyde. In addition, N-acetyl derivatives of compounds 2d-2g were also prepared. The structures of eleven new compounds synthesized were determined by elemental analysis as well as IR, NMR and UV spectral data. In addition, compounds 2a-g and 3a, 3b, 3d-f were also screened for their antioxidant activities and 2a-g were potentiometrically titrated with tetrabutylammonium hydroxide (TBAH) in four nonaqueous solvents (isopropyl alcohol, t-butyl alcohol, acetonitrile and N,N-dimethyl formamide). Also half-neutralization potential values and the corresponding pKa values were determined in all cases.http://dx.doi.org/10.1155/2011/635459 |
| spellingShingle | H. Yuksek F. Islamoglu O. Gursoy Kol S. Bahceci M. Bekar M. Aksoy In Virto Antioxidant Activities of New 4,5-Dihydro-1H,2,4-triazol-5-ones having Thiophene Ring with their Acidic Properties E-Journal of Chemistry |
| title | In Virto Antioxidant Activities of New 4,5-Dihydro-1H,2,4-triazol-5-ones having Thiophene Ring with their Acidic Properties |
| title_full | In Virto Antioxidant Activities of New 4,5-Dihydro-1H,2,4-triazol-5-ones having Thiophene Ring with their Acidic Properties |
| title_fullStr | In Virto Antioxidant Activities of New 4,5-Dihydro-1H,2,4-triazol-5-ones having Thiophene Ring with their Acidic Properties |
| title_full_unstemmed | In Virto Antioxidant Activities of New 4,5-Dihydro-1H,2,4-triazol-5-ones having Thiophene Ring with their Acidic Properties |
| title_short | In Virto Antioxidant Activities of New 4,5-Dihydro-1H,2,4-triazol-5-ones having Thiophene Ring with their Acidic Properties |
| title_sort | in virto antioxidant activities of new 4 5 dihydro 1h 2 4 triazol 5 ones having thiophene ring with their acidic properties |
| url | http://dx.doi.org/10.1155/2011/635459 |
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