A radiomics-based interpretable machine learning model to predict the HER2 status in bladder cancer: a multicenter study
Abstract Objective To develop a computed tomography (CT) radiomics-based interpretable machine learning (ML) model to preoperatively predict human epidermal growth factor receptor 2 (HER2) status in bladder cancer (BCa) with multicenter validation. Methods In this retrospective study, 207 patients w...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-10-01
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| Series: | Insights into Imaging |
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| Online Access: | https://doi.org/10.1186/s13244-024-01840-3 |
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| author | Zongjie Wei Xuesong Bai Yingjie Xv Shao-Hao Chen Siwen Yin Yang Li Fajin Lv Mingzhao Xiao Yongpeng Xie |
| author_facet | Zongjie Wei Xuesong Bai Yingjie Xv Shao-Hao Chen Siwen Yin Yang Li Fajin Lv Mingzhao Xiao Yongpeng Xie |
| author_sort | Zongjie Wei |
| collection | DOAJ |
| description | Abstract Objective To develop a computed tomography (CT) radiomics-based interpretable machine learning (ML) model to preoperatively predict human epidermal growth factor receptor 2 (HER2) status in bladder cancer (BCa) with multicenter validation. Methods In this retrospective study, 207 patients with pathologically confirmed BCa were enrolled and divided into the training set (n = 154) and test set (n = 53). Least absolute shrinkage and selection operator (LASSO) regression was used to identify the most discriminative features in the training set. Five radiomics-based ML models, namely logistic regression (LR), support vector machine (SVM), k-nearest neighbors (KNN), eXtreme Gradient Boosting (XGBoost) and random forest (RF), were developed. The predictive performance of established ML models was evaluated by the area under the receiver operating characteristic curve (AUC). The Shapley additive explanation (SHAP) was used to analyze the interpretability of ML models. Results A total of 1218 radiomics features were extracted from the nephrographic phase CT images, and 11 features were filtered for constructing ML models. In the test set, the AUCs of LR, SVM, KNN, XGBoost, and RF were 0.803, 0.709, 0.679, 0.794, and 0.815, with corresponding accuracies of 71.7%, 69.8%, 60.4%, 75.5%, and 75.5%, respectively. RF was identified as the optimal classifier. SHAP analysis showed that texture features (gray level size zone matrix and gray level co-occurrence matrix) were significant predictors of HER2 status. Conclusions The radiomics-based interpretable ML model provides a noninvasive tool to predict the HER2 status of BCa with satisfactory discriminatory performance. Critical relevance statement An interpretable radiomics-based machine learning model can preoperatively predict HER2 status in bladder cancer, potentially aiding in the clinical decision-making process. Key Points The CT radiomics model could identify HER2 status in bladder cancer. The random forest model showed a more robust and accurate performance. The model demonstrated favorable interpretability through SHAP method. Graphical Abstract |
| format | Article |
| id | doaj-art-85431007c8e244a08305dd125c269f39 |
| institution | OA Journals |
| issn | 1869-4101 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Insights into Imaging |
| spelling | doaj-art-85431007c8e244a08305dd125c269f392025-08-20T02:18:24ZengSpringerOpenInsights into Imaging1869-41012024-10-0115111110.1186/s13244-024-01840-3A radiomics-based interpretable machine learning model to predict the HER2 status in bladder cancer: a multicenter studyZongjie Wei0Xuesong Bai1Yingjie Xv2Shao-Hao Chen3Siwen Yin4Yang Li5Fajin Lv6Mingzhao Xiao7Yongpeng Xie8Department of Urology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Urology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Urology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Urology, Urology Research Institute, The First Affiliated Hospital of Fujian Medical UniversityDepartment of Urology, Chongqing University Fuling HospitalDepartment of Urology, Chongqing University Three Gorges HospitalDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Urology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Urology, The First Affiliated Hospital of Chongqing Medical UniversityAbstract Objective To develop a computed tomography (CT) radiomics-based interpretable machine learning (ML) model to preoperatively predict human epidermal growth factor receptor 2 (HER2) status in bladder cancer (BCa) with multicenter validation. Methods In this retrospective study, 207 patients with pathologically confirmed BCa were enrolled and divided into the training set (n = 154) and test set (n = 53). Least absolute shrinkage and selection operator (LASSO) regression was used to identify the most discriminative features in the training set. Five radiomics-based ML models, namely logistic regression (LR), support vector machine (SVM), k-nearest neighbors (KNN), eXtreme Gradient Boosting (XGBoost) and random forest (RF), were developed. The predictive performance of established ML models was evaluated by the area under the receiver operating characteristic curve (AUC). The Shapley additive explanation (SHAP) was used to analyze the interpretability of ML models. Results A total of 1218 radiomics features were extracted from the nephrographic phase CT images, and 11 features were filtered for constructing ML models. In the test set, the AUCs of LR, SVM, KNN, XGBoost, and RF were 0.803, 0.709, 0.679, 0.794, and 0.815, with corresponding accuracies of 71.7%, 69.8%, 60.4%, 75.5%, and 75.5%, respectively. RF was identified as the optimal classifier. SHAP analysis showed that texture features (gray level size zone matrix and gray level co-occurrence matrix) were significant predictors of HER2 status. Conclusions The radiomics-based interpretable ML model provides a noninvasive tool to predict the HER2 status of BCa with satisfactory discriminatory performance. Critical relevance statement An interpretable radiomics-based machine learning model can preoperatively predict HER2 status in bladder cancer, potentially aiding in the clinical decision-making process. Key Points The CT radiomics model could identify HER2 status in bladder cancer. The random forest model showed a more robust and accurate performance. The model demonstrated favorable interpretability through SHAP method. Graphical Abstracthttps://doi.org/10.1186/s13244-024-01840-3RadiomicsBladder cancerComputed tomographyHER2Machine learning |
| spellingShingle | Zongjie Wei Xuesong Bai Yingjie Xv Shao-Hao Chen Siwen Yin Yang Li Fajin Lv Mingzhao Xiao Yongpeng Xie A radiomics-based interpretable machine learning model to predict the HER2 status in bladder cancer: a multicenter study Insights into Imaging Radiomics Bladder cancer Computed tomography HER2 Machine learning |
| title | A radiomics-based interpretable machine learning model to predict the HER2 status in bladder cancer: a multicenter study |
| title_full | A radiomics-based interpretable machine learning model to predict the HER2 status in bladder cancer: a multicenter study |
| title_fullStr | A radiomics-based interpretable machine learning model to predict the HER2 status in bladder cancer: a multicenter study |
| title_full_unstemmed | A radiomics-based interpretable machine learning model to predict the HER2 status in bladder cancer: a multicenter study |
| title_short | A radiomics-based interpretable machine learning model to predict the HER2 status in bladder cancer: a multicenter study |
| title_sort | radiomics based interpretable machine learning model to predict the her2 status in bladder cancer a multicenter study |
| topic | Radiomics Bladder cancer Computed tomography HER2 Machine learning |
| url | https://doi.org/10.1186/s13244-024-01840-3 |
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