Study on the Toxicological Impacts of Intraperitoneal Microcystin-LR Injection on GIFT Tilapia (<i>Oreochromis niloticus</i>) Through Multi-Omics Analysis
This study employed multi-omics analysis to systematically evaluate the toxic effects of intraperitoneal injection of MC-LR on GIFT tilapia. The results showed that 96 h post injection, serum levels of aspartate GOT, GPT, LYZ, T-AOC, and SOD significantly decreased (<i>p</i> < 0.05)....
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MDPI AG
2025-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/14/3/296 |
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| author | Haizheng Wu Haojun Zhu Quanjie Li Jiancao Gao Jinliang Du Liping Cao Yi Sun Gangchun Xu |
| author_facet | Haizheng Wu Haojun Zhu Quanjie Li Jiancao Gao Jinliang Du Liping Cao Yi Sun Gangchun Xu |
| author_sort | Haizheng Wu |
| collection | DOAJ |
| description | This study employed multi-omics analysis to systematically evaluate the toxic effects of intraperitoneal injection of MC-LR on GIFT tilapia. The results showed that 96 h post injection, serum levels of aspartate GOT, GPT, LYZ, T-AOC, and SOD significantly decreased (<i>p</i> < 0.05). In contrast, hepatic levels of CAT and MDA significantly increased. The 16S rDNA sequencing method revealed a significant reduction in the α diversity of the intestinal microbiota. At the phylum level, the relative abundances of Firmicutes and Bacteroidota significantly decreased; at the genus level, several genera, including <i>Bacteroides</i> and <i>Pseudomonas</i>, also exhibited significant changes. Functional prediction indicated that the affected pathways were primarily related to metabolism and disease. Additionally, targeted metabolomics analysis showed a significant decrease in the levels of several SCFAs, such as butyric acid. Correlation analysis further elucidated the complex interactions between the intestinal microbiota, biochemical indicators, and SCFA metabolism. Overall, the study demonstrated that MC-LR induced oxidative stress and liver damage and led to intestinal microbiota imbalance and metabolic dysfunction in GIFT tilapia. |
| format | Article |
| id | doaj-art-853d8c2db22540909b7aea057d5e1586 |
| institution | OA Journals |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-853d8c2db22540909b7aea057d5e15862025-08-20T02:11:21ZengMDPI AGAntioxidants2076-39212025-02-0114329610.3390/antiox14030296Study on the Toxicological Impacts of Intraperitoneal Microcystin-LR Injection on GIFT Tilapia (<i>Oreochromis niloticus</i>) Through Multi-Omics AnalysisHaizheng Wu0Haojun Zhu1Quanjie Li2Jiancao Gao3Jinliang Du4Liping Cao5Yi Sun6Gangchun Xu7Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, ChinaKey Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, ChinaKey Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, ChinaKey Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, ChinaWuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, ChinaWuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, ChinaKey Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, ChinaWuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, ChinaThis study employed multi-omics analysis to systematically evaluate the toxic effects of intraperitoneal injection of MC-LR on GIFT tilapia. The results showed that 96 h post injection, serum levels of aspartate GOT, GPT, LYZ, T-AOC, and SOD significantly decreased (<i>p</i> < 0.05). In contrast, hepatic levels of CAT and MDA significantly increased. The 16S rDNA sequencing method revealed a significant reduction in the α diversity of the intestinal microbiota. At the phylum level, the relative abundances of Firmicutes and Bacteroidota significantly decreased; at the genus level, several genera, including <i>Bacteroides</i> and <i>Pseudomonas</i>, also exhibited significant changes. Functional prediction indicated that the affected pathways were primarily related to metabolism and disease. Additionally, targeted metabolomics analysis showed a significant decrease in the levels of several SCFAs, such as butyric acid. Correlation analysis further elucidated the complex interactions between the intestinal microbiota, biochemical indicators, and SCFA metabolism. Overall, the study demonstrated that MC-LR induced oxidative stress and liver damage and led to intestinal microbiota imbalance and metabolic dysfunction in GIFT tilapia.https://www.mdpi.com/2076-3921/14/3/296microcystin-LRGIFT tilapiaoxidative stressintestinal microbiotaSCFAs |
| spellingShingle | Haizheng Wu Haojun Zhu Quanjie Li Jiancao Gao Jinliang Du Liping Cao Yi Sun Gangchun Xu Study on the Toxicological Impacts of Intraperitoneal Microcystin-LR Injection on GIFT Tilapia (<i>Oreochromis niloticus</i>) Through Multi-Omics Analysis Antioxidants microcystin-LR GIFT tilapia oxidative stress intestinal microbiota SCFAs |
| title | Study on the Toxicological Impacts of Intraperitoneal Microcystin-LR Injection on GIFT Tilapia (<i>Oreochromis niloticus</i>) Through Multi-Omics Analysis |
| title_full | Study on the Toxicological Impacts of Intraperitoneal Microcystin-LR Injection on GIFT Tilapia (<i>Oreochromis niloticus</i>) Through Multi-Omics Analysis |
| title_fullStr | Study on the Toxicological Impacts of Intraperitoneal Microcystin-LR Injection on GIFT Tilapia (<i>Oreochromis niloticus</i>) Through Multi-Omics Analysis |
| title_full_unstemmed | Study on the Toxicological Impacts of Intraperitoneal Microcystin-LR Injection on GIFT Tilapia (<i>Oreochromis niloticus</i>) Through Multi-Omics Analysis |
| title_short | Study on the Toxicological Impacts of Intraperitoneal Microcystin-LR Injection on GIFT Tilapia (<i>Oreochromis niloticus</i>) Through Multi-Omics Analysis |
| title_sort | study on the toxicological impacts of intraperitoneal microcystin lr injection on gift tilapia i oreochromis niloticus i through multi omics analysis |
| topic | microcystin-LR GIFT tilapia oxidative stress intestinal microbiota SCFAs |
| url | https://www.mdpi.com/2076-3921/14/3/296 |
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