Thyroid Hormone Supplementation Restores Cognitive Deficit, Insulin Signaling, and Neuroinflammation in the Hippocampus of a Sporadic Alzheimer’s-like Disease Rat Model

Thyroid Hormone Supplementation Restores Cognitive Deficit, Insulin Signaling, and Neuroinflammation in the Hippocampus of a Sporadic Alzheimer’s-like Disease Rat Model

Thyroid hormones play a crucial role in the development of the central nervous system and are considered pivotal to cognitive functions in the adult brain. Recently, thyroid dysfunction has been associated with Alzheimer’s disease. The aim of this study was to assess the neuroprotective effects of t...

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Bibliographic Details
Main Authors: Paulina Sepúlveda, Ana Flavia Fernandes Ferreira, Cristian Sandoval, Giovanna Bergoc, Ana Caroline Rippi Moreno, Maria Tereza Nunes, Andréa da Silva Torrão
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Cells
Subjects:
Alzheimer’s disease
insulin signaling
neurodegeneration
triiodothyronine
streptozotocin
Online Access:https://www.mdpi.com/2073-4409/13/21/1793
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