The effect of aqueous Stevia rebaudiana extract and clomiphene citrate on the expression of GDF9, PTEN, BMP15 genes, and antioxidant levels in a letrozole-induced polycystic ovary syndrome model in Wistar rats

The effect of aqueous Stevia rebaudiana extract and clomiphene citrate on the expression of GDF9, PTEN, BMP15 genes, and antioxidant levels in a letrozole-induced polycystic ovary syndrome model in Wistar rats

Abstract This study investigates the individual and combined effects of aqueous Stevia rebaudiana extract (SAE) and clomiphene citrate (Clom) on the expression of key ovarian regulatory genes -growth differentiation factor 9 (GDF9), phosphatase and tensin homolog (PTEN), and bone morphogenetic prote...

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Main Authors: Alireza Saedi, Mehdi Mahmoodi, Reza Hosseiniara, Mahboubeh Vatanparast, Amir Hossein Fatehi Marj, Javad Paran Nejad, Moein Moradi, Sadegh Zarei
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Ovarian Research
Subjects:
Polycystic ovary syndrome
Wistar rats
Gene expression
Antioxidants
Stevia rebaudiana
Clomiphene citrate
Online Access:https://doi.org/10.1186/s13048-025-01719-x
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