The influence of changes in hospital drug formulary on the prescription of proton pump inhibitors
Objective: To analyze the impact of introducing omeprazole in the drug formulary of the Hospital de Barbanza on prescriptions made in hospital and out-of-hospital (Outpatient Units and Primary Care) for all Proton Pump Inhibitors (PPIs). Material and methods: A 36-month retrospective descriptive...
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Elsevier
2017-01-01
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| Series: | Farmacia Hospitalaria |
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| Online Access: | http://www.aulamedica.es/fh/pdf/10559.pdf |
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| author | Raquel Vázquez-Mourelle Eduardo Carracedo-Martínez |
| author_facet | Raquel Vázquez-Mourelle Eduardo Carracedo-Martínez |
| author_sort | Raquel Vázquez-Mourelle |
| collection | DOAJ |
| description | Objective: To analyze the impact of introducing omeprazole in the drug formulary of the Hospital de Barbanza on prescriptions made in
hospital and out-of-hospital (Outpatient Units and Primary Care) for all Proton Pump Inhibitors (PPIs). Material and methods: A 36-month retrospective descriptive study in a level I hospital. The basic units of work are Dose-Population- Day in the outpatient setting, and the Defined Daily Dose/stays-day for hospitalized patients; the proportion of DDDs for omeprazole vs. the rest of PPIs is used as measure of efficiency. For statistical analysis, we built a segmented regression model. Results: In the outpatient units, there are statistically significant changes for pantoprazole and rabeprazole. The first drug, which was stable before the intervention, suffered an immediate decrease; rabeprazole, which was increasing before the intervention, presented a subsequent downward trend. In Primary Care, a statistically significant change was confirmed for pantoprazole, with a long-term decreasing trend. In hospitalization, statistically significant changes were observed for pantoprazole and omeprazole; the first one with an immediate decrease and a long-term tendency to decrease, while omeprazole experienced
an immediate increase and long-term growth. The evolution of the omeprazole percentage vs. all PPIs showed increases in all three scenarios. Conclusions: A shift to a more efficient prescription of PPIs was observed in all healthcare settings following the introduction of omeprazole in the hospital drug formulary. The inclusion of efficient drugs, or the removal of those inefficient, can be a potentially useful tool in order to improve prescription profiles. |
| format | Article |
| id | doaj-art-8519973bb9c84f06ab36a03fa4e8cd1d |
| institution | DOAJ |
| issn | 1130-6343 2171-8695 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Farmacia Hospitalaria |
| spelling | doaj-art-8519973bb9c84f06ab36a03fa4e8cd1d2025-08-20T02:56:46ZengElsevierFarmacia Hospitalaria1130-63432171-86952017-01-01411496710.7399/fh.2017.41.1.10559The influence of changes in hospital drug formulary on the prescription of proton pump inhibitorsRaquel Vázquez-Mourelle0Eduardo Carracedo-Martínez1Assistant Manager. Galician Health Service. Xunta de Galicia. Santiago de Organizational Structure of Integrated Management System. Galician Health Objective: To analyze the impact of introducing omeprazole in the drug formulary of the Hospital de Barbanza on prescriptions made in hospital and out-of-hospital (Outpatient Units and Primary Care) for all Proton Pump Inhibitors (PPIs). Material and methods: A 36-month retrospective descriptive study in a level I hospital. The basic units of work are Dose-Population- Day in the outpatient setting, and the Defined Daily Dose/stays-day for hospitalized patients; the proportion of DDDs for omeprazole vs. the rest of PPIs is used as measure of efficiency. For statistical analysis, we built a segmented regression model. Results: In the outpatient units, there are statistically significant changes for pantoprazole and rabeprazole. The first drug, which was stable before the intervention, suffered an immediate decrease; rabeprazole, which was increasing before the intervention, presented a subsequent downward trend. In Primary Care, a statistically significant change was confirmed for pantoprazole, with a long-term decreasing trend. In hospitalization, statistically significant changes were observed for pantoprazole and omeprazole; the first one with an immediate decrease and a long-term tendency to decrease, while omeprazole experienced an immediate increase and long-term growth. The evolution of the omeprazole percentage vs. all PPIs showed increases in all three scenarios. Conclusions: A shift to a more efficient prescription of PPIs was observed in all healthcare settings following the introduction of omeprazole in the hospital drug formulary. The inclusion of efficient drugs, or the removal of those inefficient, can be a potentially useful tool in order to improve prescription profiles.http://www.aulamedica.es/fh/pdf/10559.pdfOmeprazole; Proton pump inhibitorsHospital formularyHospital Pharmacy UnitDrug prescriptionsStatistical regression analysisOrganizational efficiency; Hospital management; Public hospitalsHealthcare area with integrated management |
| spellingShingle | Raquel Vázquez-Mourelle Eduardo Carracedo-Martínez The influence of changes in hospital drug formulary on the prescription of proton pump inhibitors Farmacia Hospitalaria Omeprazole ; Proton pump inhibitors Hospital formulary Hospital Pharmacy Unit Drug prescriptions Statistical regression analysis Organizational efficiency ; Hospital management ; Public hospitals Healthcare area with integrated management |
| title | The influence of changes in hospital drug formulary on the prescription of proton pump inhibitors |
| title_full | The influence of changes in hospital drug formulary on the prescription of proton pump inhibitors |
| title_fullStr | The influence of changes in hospital drug formulary on the prescription of proton pump inhibitors |
| title_full_unstemmed | The influence of changes in hospital drug formulary on the prescription of proton pump inhibitors |
| title_short | The influence of changes in hospital drug formulary on the prescription of proton pump inhibitors |
| title_sort | influence of changes in hospital drug formulary on the prescription of proton pump inhibitors |
| topic | Omeprazole ; Proton pump inhibitors Hospital formulary Hospital Pharmacy Unit Drug prescriptions Statistical regression analysis Organizational efficiency ; Hospital management ; Public hospitals Healthcare area with integrated management |
| url | http://www.aulamedica.es/fh/pdf/10559.pdf |
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