Intravitreal steroid implants in the management of noninfectious intermediate and posterior uveitis
The management of intermediate and posterior uveitis poses a significant challenge of achieving adequate drug concentrations in the posterior segment over the chronic nature of the disease. Systemic agents seldom reach effective drug levels, and even with low maintenance or tapering doses, it is har...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Indian Journal of Ophthalmology |
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| Online Access: | https://journals.lww.com/10.4103/IJO.IJO_712_24 |
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| author | Sarjak M Shah Priya Prabhu Jyotirmay Biswas |
| author_facet | Sarjak M Shah Priya Prabhu Jyotirmay Biswas |
| author_sort | Sarjak M Shah |
| collection | DOAJ |
| description | The management of intermediate and posterior uveitis poses a significant challenge of achieving adequate drug concentrations in the posterior segment over the chronic nature of the disease. Systemic agents seldom reach effective drug levels, and even with low maintenance or tapering doses, it is hard to avoid systemic toxicity. The use of intravitreal and periocular injections is often unable to prevent recurrences due to their short half-life. Since the emergence of intravitreal implants (Vitrasert, Retisert), it has become possible to circumvent these therapeutic challenges. A detailed review in the PubMed index yielded 155 articles, of which 22 were analyzed based on exclusion criteria. A recent shift from surgically sutured to minimally invasive injectable implants mainly indicated for noninfectious uveitis is evident from the literature. This review article also provides insights into dexamethasone (Ozurdex) and recent fluocinolone acetonide (Yutiq, Iluvien) implants with particular emphasis on their improved safety and efficacy. Dexamethasone implants favor the therapeutic goal of prevention of recurrences, whereas the use of fluocinolone implants helps to attain better visual outcomes due to their longer duration of action. Thus, the review provides recent literature supporting the role and indication of sustained release intravitreal implants in the management of noninfectious intermediate and posterior uveitis. |
| format | Article |
| id | doaj-art-850e18f3898a44d290ab81d9b171e738 |
| institution | Kabale University |
| issn | 0301-4738 1998-3689 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj-art-850e18f3898a44d290ab81d9b171e7382025-01-07T06:28:38ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892025-01-0173Suppl 1S37S4610.4103/IJO.IJO_712_24Intravitreal steroid implants in the management of noninfectious intermediate and posterior uveitisSarjak M ShahPriya PrabhuJyotirmay BiswasThe management of intermediate and posterior uveitis poses a significant challenge of achieving adequate drug concentrations in the posterior segment over the chronic nature of the disease. Systemic agents seldom reach effective drug levels, and even with low maintenance or tapering doses, it is hard to avoid systemic toxicity. The use of intravitreal and periocular injections is often unable to prevent recurrences due to their short half-life. Since the emergence of intravitreal implants (Vitrasert, Retisert), it has become possible to circumvent these therapeutic challenges. A detailed review in the PubMed index yielded 155 articles, of which 22 were analyzed based on exclusion criteria. A recent shift from surgically sutured to minimally invasive injectable implants mainly indicated for noninfectious uveitis is evident from the literature. This review article also provides insights into dexamethasone (Ozurdex) and recent fluocinolone acetonide (Yutiq, Iluvien) implants with particular emphasis on their improved safety and efficacy. Dexamethasone implants favor the therapeutic goal of prevention of recurrences, whereas the use of fluocinolone implants helps to attain better visual outcomes due to their longer duration of action. Thus, the review provides recent literature supporting the role and indication of sustained release intravitreal implants in the management of noninfectious intermediate and posterior uveitis.https://journals.lww.com/10.4103/IJO.IJO_712_24fluocinolone implantsiluvienintravitreal implantsnoninfectious uveitisozurdexposterior uveitisyutiq |
| spellingShingle | Sarjak M Shah Priya Prabhu Jyotirmay Biswas Intravitreal steroid implants in the management of noninfectious intermediate and posterior uveitis Indian Journal of Ophthalmology fluocinolone implants iluvien intravitreal implants noninfectious uveitis ozurdex posterior uveitis yutiq |
| title | Intravitreal steroid implants in the management of noninfectious intermediate and posterior uveitis |
| title_full | Intravitreal steroid implants in the management of noninfectious intermediate and posterior uveitis |
| title_fullStr | Intravitreal steroid implants in the management of noninfectious intermediate and posterior uveitis |
| title_full_unstemmed | Intravitreal steroid implants in the management of noninfectious intermediate and posterior uveitis |
| title_short | Intravitreal steroid implants in the management of noninfectious intermediate and posterior uveitis |
| title_sort | intravitreal steroid implants in the management of noninfectious intermediate and posterior uveitis |
| topic | fluocinolone implants iluvien intravitreal implants noninfectious uveitis ozurdex posterior uveitis yutiq |
| url | https://journals.lww.com/10.4103/IJO.IJO_712_24 |
| work_keys_str_mv | AT sarjakmshah intravitrealsteroidimplantsinthemanagementofnoninfectiousintermediateandposterioruveitis AT priyaprabhu intravitrealsteroidimplantsinthemanagementofnoninfectiousintermediateandposterioruveitis AT jyotirmaybiswas intravitrealsteroidimplantsinthemanagementofnoninfectiousintermediateandposterioruveitis |