Explorative Study of Modulatory Effects of Notochordal Cell‐Derived Extracellular Vesicles on the IL‐1β‐Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants

Explorative Study of Modulatory Effects of Notochordal Cell‐Derived Extracellular Vesicles on the IL‐1β‐Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants

ABSTRACT Background Cell‐free regenerative strategies, such as notochordal cell (NC)‐derived extracellular vesicles (EVs), are an attractive alternative in developing new therapies for intervertebral disc (IVD) degeneration. NC‐EVs have been reported to elicit matrix anabolic effects on nucleus pulp...

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Bibliographic Details
Main Authors: J. C. vanMaanen, F. C. Bach, J. W. Snuggs, K. Ito, M. H. M. Wauben, C. L. Le Maitre, M. A. Tryfonidou
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:JOR Spine
Subjects:
CCL2
degeneration
dog
human explant
intervertebral disc
Online Access:https://doi.org/10.1002/jsp2.70043
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