Critical signaling pathways in osteoclast differentiation and bone resorption: mechanisms and therapeutic implications for periprosthetic osteolysis

Critical signaling pathways in osteoclast differentiation and bone resorption: mechanisms and therapeutic implications for periprosthetic osteolysis

Bone homeostasis is dynamically regulated by the balance between osteoclast-mediated bone resorption and osteoblast-driven bone formation. Periprosthetic osteolysis (PPO), a major complication following joint arthroplasty, occurs when excessive bone resorption surpasses formation, leading to implant...

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Bibliographic Details
Main Authors: Liangzi Yin, Chenglin Sun, Junjie Zhang, Yan Li, Yansheng Wang, Lunhao Bai, Zeming Lei
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
periprosthetic osteolysis
bone resorption
signaling pathways
osteoclasts
RANKL/RANK/OPG
NF-κB
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1639430/full
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