The protective effect of Edaravone against acute renocardiac syndrome in a kidney ischemia-reperfusion model
Introduction: Acute kidney injury (AKI) is a common clinical occurrence causing high mortality and morbidity. In acute renocardiac syndrome, AKI leads to acute cardiac injury or/and dysfunction. This study aimed to investigate the antioxidative effects of Edaravone on cardiac tissues following the i...
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| Format: | Article |
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Tabriz University of Medical Sciences
2024-12-01
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| Series: | Journal of Cardiovascular and Thoracic Research |
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| Online Access: | https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-16-243.pdf |
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| author | Yasin Bagheri Mahshid Dehghan Seyyedeh Mina Hejazian Mohammadreza Ardalan Sepideh Zununi Vahed Bahram Niknafs |
| author_facet | Yasin Bagheri Mahshid Dehghan Seyyedeh Mina Hejazian Mohammadreza Ardalan Sepideh Zununi Vahed Bahram Niknafs |
| author_sort | Yasin Bagheri |
| collection | DOAJ |
| description | Introduction: Acute kidney injury (AKI) is a common clinical occurrence causing high mortality and morbidity. In acute renocardiac syndrome, AKI leads to acute cardiac injury or/and dysfunction. This study aimed to investigate the antioxidative effects of Edaravone on cardiac tissues following the induction of renal ischemia-reperfusion injury (IRI) in rats. Methods: Twenty-four male Wistar rats were randomly divided into four groups: IR+Edaravone, Edaravone, IR, and Sham groups (six rats per group). Non-traumatic clamps were used to stop the artery and vein blood flow of the left kidney in rats of the IR groups for 45 minutes. Thirty minutes before ischemia induction, Edaravone (3 mg/kg) was injected intraperitoneally in the IR+Edaravone group. Cardiac samples were subjected to biochemical analyses. Results: The Results showed a significant increase in the enzymatic activity of glutathione peroxidase (P=0.01), catalase (P=0.03), and superoxide dismutase (P=0.02), and the levels of glutathione (P=0.012), and total antioxidant capacity (P<0.001) in the IR+Edaravone group in comparison to the IR group. Moreover, the total antioxidant capacity of the heart was increased in the Edaravone group compared to the control and IR groups (P<0.001), indicating the safety of the drug. Conclusion: The results can reveal important insights into the protective effects of Edaravone against acute renocardiac syndrome. |
| format | Article |
| id | doaj-art-85029c8a184742f796562f5a30e4a7a0 |
| institution | OA Journals |
| issn | 2008-5117 2008-6830 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Journal of Cardiovascular and Thoracic Research |
| spelling | doaj-art-85029c8a184742f796562f5a30e4a7a02025-08-20T01:57:52ZengTabriz University of Medical SciencesJournal of Cardiovascular and Thoracic Research2008-51172008-68302024-12-0116424324810.34172/jcvtr.33077jcvtr-33077The protective effect of Edaravone against acute renocardiac syndrome in a kidney ischemia-reperfusion modelYasin Bagheri0Mahshid Dehghan1Seyyedeh Mina Hejazian2Mohammadreza Ardalan3Sepideh Zununi Vahed4Bahram Niknafs5Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, IranFaculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranKidney Research Center, Tabriz University of Medical Sciences, Tabriz, IranKidney Research Center, Tabriz University of Medical Sciences, Tabriz, IranKidney Research Center, Tabriz University of Medical Sciences, Tabriz, IranKidney Research Center, Tabriz University of Medical Sciences, Tabriz, IranIntroduction: Acute kidney injury (AKI) is a common clinical occurrence causing high mortality and morbidity. In acute renocardiac syndrome, AKI leads to acute cardiac injury or/and dysfunction. This study aimed to investigate the antioxidative effects of Edaravone on cardiac tissues following the induction of renal ischemia-reperfusion injury (IRI) in rats. Methods: Twenty-four male Wistar rats were randomly divided into four groups: IR+Edaravone, Edaravone, IR, and Sham groups (six rats per group). Non-traumatic clamps were used to stop the artery and vein blood flow of the left kidney in rats of the IR groups for 45 minutes. Thirty minutes before ischemia induction, Edaravone (3 mg/kg) was injected intraperitoneally in the IR+Edaravone group. Cardiac samples were subjected to biochemical analyses. Results: The Results showed a significant increase in the enzymatic activity of glutathione peroxidase (P=0.01), catalase (P=0.03), and superoxide dismutase (P=0.02), and the levels of glutathione (P=0.012), and total antioxidant capacity (P<0.001) in the IR+Edaravone group in comparison to the IR group. Moreover, the total antioxidant capacity of the heart was increased in the Edaravone group compared to the control and IR groups (P<0.001), indicating the safety of the drug. Conclusion: The results can reveal important insights into the protective effects of Edaravone against acute renocardiac syndrome.https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-16-243.pdfedaravoneischemia-reperfusionantioxidantscardiorenal syndrome |
| spellingShingle | Yasin Bagheri Mahshid Dehghan Seyyedeh Mina Hejazian Mohammadreza Ardalan Sepideh Zununi Vahed Bahram Niknafs The protective effect of Edaravone against acute renocardiac syndrome in a kidney ischemia-reperfusion model Journal of Cardiovascular and Thoracic Research edaravone ischemia-reperfusion antioxidants cardiorenal syndrome |
| title | The protective effect of Edaravone against acute renocardiac syndrome in a kidney ischemia-reperfusion model |
| title_full | The protective effect of Edaravone against acute renocardiac syndrome in a kidney ischemia-reperfusion model |
| title_fullStr | The protective effect of Edaravone against acute renocardiac syndrome in a kidney ischemia-reperfusion model |
| title_full_unstemmed | The protective effect of Edaravone against acute renocardiac syndrome in a kidney ischemia-reperfusion model |
| title_short | The protective effect of Edaravone against acute renocardiac syndrome in a kidney ischemia-reperfusion model |
| title_sort | protective effect of edaravone against acute renocardiac syndrome in a kidney ischemia reperfusion model |
| topic | edaravone ischemia-reperfusion antioxidants cardiorenal syndrome |
| url | https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-16-243.pdf |
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