Allogeneic Hematopoietic Stem Cell Transplantation for a BCR-FGFR1 Myeloproliferative Neoplasm Presenting as Acute Lymphoblastic Leukemia
Hematopoietic myeloproliferative neoplasms (MPNS) with rearrangements of the receptor tyrosine kinase FGFR1 gene, located on chromosome 8p11, are uncommon and associated with diverse presentations such as atypical chronic myeloid leukemia, acute myeloid leukemia, or an acute T- or B-lymphoblastic le...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/620967 |
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| author | Karl Haslam Stephen E. Langabeer Johanna Kelly Natasha Coen Niamh M. O’Connell Eibhlin Conneally |
| author_facet | Karl Haslam Stephen E. Langabeer Johanna Kelly Natasha Coen Niamh M. O’Connell Eibhlin Conneally |
| author_sort | Karl Haslam |
| collection | DOAJ |
| description | Hematopoietic myeloproliferative neoplasms (MPNS) with rearrangements of the receptor tyrosine kinase FGFR1 gene, located on chromosome 8p11, are uncommon and associated with diverse presentations such as atypical chronic myeloid leukemia, acute myeloid leukemia, or an acute T- or B-lymphoblastic leukemia, reflecting the hematopoietic stem cell origin of the disease. A review of MPN patients with the t(8;22) translocation that results in a chimeric BCR-FGFR1 fusion gene reveals that this disease either presents or rapidly transforms into an acute leukemia that is generally unresponsive to currently available chemotherapeutic regimens including tyrosine kinase inhibitors (TKIS). The first case of a rare BCR-FGFR1 MPN presenting in a B-acute lymphoblastic phase who underwent allogeneic hematopoietic stem cell transplantation (HSCT) with a subsequent sustained complete molecular remission is described. Allogeneic HSCT is currently the only available therapy capable of achieving long-term remission in BCR-FGFR1 MPN patients. |
| format | Article |
| id | doaj-art-84f9c065d1744312a697f3360f4d84a6 |
| institution | OA Journals |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-84f9c065d1744312a697f3360f4d84a62025-08-20T02:08:42ZengWileyCase Reports in Hematology2090-65602090-65792012-01-01201210.1155/2012/620967620967Allogeneic Hematopoietic Stem Cell Transplantation for a BCR-FGFR1 Myeloproliferative Neoplasm Presenting as Acute Lymphoblastic LeukemiaKarl Haslam0Stephen E. Langabeer1Johanna Kelly2Natasha Coen3Niamh M. O’Connell4Eibhlin Conneally5Cancer Molecular Diagnostics, Central Pathology Laboratory, St. James’s Hospital, Dublin 8, IrelandCancer Molecular Diagnostics, Central Pathology Laboratory, St. James’s Hospital, Dublin 8, IrelandNational Centre for Medical Genetics, Our Lady’s Children’s Hospital, Dublin 12, IrelandNational Centre for Medical Genetics, Our Lady’s Children’s Hospital, Dublin 12, IrelandDepartment of Haematology, St. James’s Hospital, Dublin 8, IrelandDepartment of Haematology, St. James’s Hospital, Dublin 8, IrelandHematopoietic myeloproliferative neoplasms (MPNS) with rearrangements of the receptor tyrosine kinase FGFR1 gene, located on chromosome 8p11, are uncommon and associated with diverse presentations such as atypical chronic myeloid leukemia, acute myeloid leukemia, or an acute T- or B-lymphoblastic leukemia, reflecting the hematopoietic stem cell origin of the disease. A review of MPN patients with the t(8;22) translocation that results in a chimeric BCR-FGFR1 fusion gene reveals that this disease either presents or rapidly transforms into an acute leukemia that is generally unresponsive to currently available chemotherapeutic regimens including tyrosine kinase inhibitors (TKIS). The first case of a rare BCR-FGFR1 MPN presenting in a B-acute lymphoblastic phase who underwent allogeneic hematopoietic stem cell transplantation (HSCT) with a subsequent sustained complete molecular remission is described. Allogeneic HSCT is currently the only available therapy capable of achieving long-term remission in BCR-FGFR1 MPN patients.http://dx.doi.org/10.1155/2012/620967 |
| spellingShingle | Karl Haslam Stephen E. Langabeer Johanna Kelly Natasha Coen Niamh M. O’Connell Eibhlin Conneally Allogeneic Hematopoietic Stem Cell Transplantation for a BCR-FGFR1 Myeloproliferative Neoplasm Presenting as Acute Lymphoblastic Leukemia Case Reports in Hematology |
| title | Allogeneic Hematopoietic Stem Cell Transplantation for a BCR-FGFR1 Myeloproliferative Neoplasm Presenting as Acute Lymphoblastic Leukemia |
| title_full | Allogeneic Hematopoietic Stem Cell Transplantation for a BCR-FGFR1 Myeloproliferative Neoplasm Presenting as Acute Lymphoblastic Leukemia |
| title_fullStr | Allogeneic Hematopoietic Stem Cell Transplantation for a BCR-FGFR1 Myeloproliferative Neoplasm Presenting as Acute Lymphoblastic Leukemia |
| title_full_unstemmed | Allogeneic Hematopoietic Stem Cell Transplantation for a BCR-FGFR1 Myeloproliferative Neoplasm Presenting as Acute Lymphoblastic Leukemia |
| title_short | Allogeneic Hematopoietic Stem Cell Transplantation for a BCR-FGFR1 Myeloproliferative Neoplasm Presenting as Acute Lymphoblastic Leukemia |
| title_sort | allogeneic hematopoietic stem cell transplantation for a bcr fgfr1 myeloproliferative neoplasm presenting as acute lymphoblastic leukemia |
| url | http://dx.doi.org/10.1155/2012/620967 |
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