Electroacupuncture produces analgesic effects via cannabinoid CB1 receptor-mediated GABAergic neuronal inhibition in the rostral ventromedial medulla

Electroacupuncture produces analgesic effects via cannabinoid CB1 receptor-mediated GABAergic neuronal inhibition in the rostral ventromedial medulla

Abstract Objective Electroacupuncture (EA) is commonly used for pain control in clinical practice, yet the precise mechanisms underlying its action are not fully understood. The rostral ventromedial medulla (RVM) plays a crucial role in the modulation of pain. GABAergic neurons in the RVM (GABARVM n...

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Bibliographic Details
Main Authors: Kexing Wan, Qian Xu, Yulong Shi, Chi Cui, Jie Lei, Kailing Zhang, Qingxu Yao, Yiqing Rao, Ziyu Zhou, Yisong Wu, Jiale Mei, Hui-Lin Pan, Xianghong Jing, He Zhu, Man Li
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Chinese Medicine
Subjects:
Acupuncture
Inflammatory pain
Neuropathic pain
Cannabinoid Receptors
Rostroventromedial Medulla
GABA neuron
Online Access:https://doi.org/10.1186/s13020-025-01083-4
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