Utility of 99mTechnetium Pertechnetate Thyroid Scan and Uptake in Thyrotoxic Patients: Jordanian Experience
Objective The objective of this study was to assess our local experience with 99mTechnitium thyroid uptake (TcTU) in thyrotoxicosis by examining mean and range of TcTU in both euthyroid patients and thyrotoxic patients. We also wanted to see how well TcTU performed as a substitute for radioiodine th...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2022-09-01
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| Series: | World Journal of Nuclear Medicine |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1751053 |
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| author | Kusai M. Al-Muqbel |
| author_facet | Kusai M. Al-Muqbel |
| author_sort | Kusai M. Al-Muqbel |
| collection | DOAJ |
| description | Objective The objective of this study was to assess our local experience with 99mTechnitium thyroid uptake (TcTU) in thyrotoxicosis by examining mean and range of TcTU in both euthyroid patients and thyrotoxic patients. We also wanted to see how well TcTU performed as a substitute for radioiodine thyroid uptake in thyrotoxicosis.
Methods The medical records of thyrotoxic patients were reviewed retrospectively. Inclusion criteria were: (1) thyrotoxicosis was proven biochemically, (2) the patient underwent TcTU at the time of thyrotoxicosis diagnosis, (3) at least 6 months of follow-up, and (4) the final diagnosis was documented. All TcTU of euthyroid patients were also reviewed to determine local normal TcTU mean and range. Patients were divided into three groups: Graves' disease, toxic nodular goiter, and subacute thyroiditis. Each patient group's TcTU mean and range were assessed separately.
Results There were 209 patients in total (54 euthyroid, 112 Graves' disease, 26 toxic nodules, and 17 patients with subacute thyroiditis). TcTU mean±standard deviation and range for euthyroid patients were 1.5±1.1% and 0.17 to 4.8%, 10.6±10% and 0.43 to 40% for Graves' disease, 4.5±4% and 0.6 to 15% for toxic nodules, and 0.5±0.4% and 0.18 to 1% for subacute thyroiditis. Although one-third of thyrotoxic patients' TcTU values overlapped with the normal TcTU range, the diagnosis was made using qualitative image analysis. Subacute thyroiditis was characterized by poor thyroid visualization, whereas Graves'/toxic nodular goiter was well visualized.
Conclusion The mean and range of our local normal TcTU were similar to those previously published. TcTU was a useful alternative to radioiodine in the evaluation of thyrotoxicosis. About two-thirds of the patients had accurate test results. The diagnosis was reached in the remaining one-third of patients by combining quantitative and qualitative image features. This method allowed us to stop giving radioiodine to our patients, resulting in a significant reduction in patient radiation exposure. |
| format | Article |
| id | doaj-art-84f049d0dede49aa861466a916bfa5fa |
| institution | DOAJ |
| issn | 1450-1147 1607-3312 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | World Journal of Nuclear Medicine |
| spelling | doaj-art-84f049d0dede49aa861466a916bfa5fa2025-08-20T03:04:39ZengThieme Medical and Scientific Publishers Pvt. Ltd.World Journal of Nuclear Medicine1450-11471607-33122022-09-0110.1055/s-0042-1751053Utility of 99mTechnetium Pertechnetate Thyroid Scan and Uptake in Thyrotoxic Patients: Jordanian ExperienceKusai M. Al-Muqbel0Faculty of Medicine, Department of Radiology and Nuclear Medicine, Jordan University of Science and Technology, Irbid, JordanObjective The objective of this study was to assess our local experience with 99mTechnitium thyroid uptake (TcTU) in thyrotoxicosis by examining mean and range of TcTU in both euthyroid patients and thyrotoxic patients. We also wanted to see how well TcTU performed as a substitute for radioiodine thyroid uptake in thyrotoxicosis. Methods The medical records of thyrotoxic patients were reviewed retrospectively. Inclusion criteria were: (1) thyrotoxicosis was proven biochemically, (2) the patient underwent TcTU at the time of thyrotoxicosis diagnosis, (3) at least 6 months of follow-up, and (4) the final diagnosis was documented. All TcTU of euthyroid patients were also reviewed to determine local normal TcTU mean and range. Patients were divided into three groups: Graves' disease, toxic nodular goiter, and subacute thyroiditis. Each patient group's TcTU mean and range were assessed separately. Results There were 209 patients in total (54 euthyroid, 112 Graves' disease, 26 toxic nodules, and 17 patients with subacute thyroiditis). TcTU mean±standard deviation and range for euthyroid patients were 1.5±1.1% and 0.17 to 4.8%, 10.6±10% and 0.43 to 40% for Graves' disease, 4.5±4% and 0.6 to 15% for toxic nodules, and 0.5±0.4% and 0.18 to 1% for subacute thyroiditis. Although one-third of thyrotoxic patients' TcTU values overlapped with the normal TcTU range, the diagnosis was made using qualitative image analysis. Subacute thyroiditis was characterized by poor thyroid visualization, whereas Graves'/toxic nodular goiter was well visualized. Conclusion The mean and range of our local normal TcTU were similar to those previously published. TcTU was a useful alternative to radioiodine in the evaluation of thyrotoxicosis. About two-thirds of the patients had accurate test results. The diagnosis was reached in the remaining one-third of patients by combining quantitative and qualitative image features. This method allowed us to stop giving radioiodine to our patients, resulting in a significant reduction in patient radiation exposure.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1751053thyroid uptaketechnetium-99mthyrotoxicosisradioiodinegraves' diseasetoxic nodular goiter |
| spellingShingle | Kusai M. Al-Muqbel Utility of 99mTechnetium Pertechnetate Thyroid Scan and Uptake in Thyrotoxic Patients: Jordanian Experience World Journal of Nuclear Medicine thyroid uptake technetium-99m thyrotoxicosis radioiodine graves' disease toxic nodular goiter |
| title | Utility of 99mTechnetium Pertechnetate Thyroid Scan and Uptake in Thyrotoxic Patients: Jordanian Experience |
| title_full | Utility of 99mTechnetium Pertechnetate Thyroid Scan and Uptake in Thyrotoxic Patients: Jordanian Experience |
| title_fullStr | Utility of 99mTechnetium Pertechnetate Thyroid Scan and Uptake in Thyrotoxic Patients: Jordanian Experience |
| title_full_unstemmed | Utility of 99mTechnetium Pertechnetate Thyroid Scan and Uptake in Thyrotoxic Patients: Jordanian Experience |
| title_short | Utility of 99mTechnetium Pertechnetate Thyroid Scan and Uptake in Thyrotoxic Patients: Jordanian Experience |
| title_sort | utility of 99mtechnetium pertechnetate thyroid scan and uptake in thyrotoxic patients jordanian experience |
| topic | thyroid uptake technetium-99m thyrotoxicosis radioiodine graves' disease toxic nodular goiter |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1751053 |
| work_keys_str_mv | AT kusaimalmuqbel utilityof99mtechnetiumpertechnetatethyroidscananduptakeinthyrotoxicpatientsjordanianexperience |