Antihypoxic activity of zinc acetate complexes with N-allenyl- and N-isopropenylimidazoles on hypoxia models of various ethiology
А comparative study of antihypoxic effect of complex compounds of zinc acetate with N-allenyland N-isopropenylimidazole, complexes immobilized on the sulfated arabinogalactan, and well-known antihypoxants, and/or antioxidants: ethomerzol, mexidol and nooglutyl has been conducted on nonlinear white mi...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
2016-09-01
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| Series: | Сеченовский вестник |
| Subjects: | |
| Online Access: | https://www.sechenovmedj.com/jour/article/view/650 |
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| Summary: | А comparative study of antihypoxic effect of complex compounds of zinc acetate with N-allenyland N-isopropenylimidazole, complexes immobilized on the sulfated arabinogalactan, and well-known antihypoxants, and/or antioxidants: ethomerzol, mexidol and nooglutyl has been conducted on nonlinear white mice-males in experiments. It is shown that in conditions of acute hypoxia of different Genesis, the complexes of zinc with N-alkenylmidazoles showed a pronounced antihypoxic effect in the dose range of 10–100 mg/kg, i/p, on 16–317% life span of animals increasing compared with the control groups of animals that surpasses the effect of known antihypoxants: etomerzol (25–100 mg/kg, i/p), mexidol (100 mg/kg, i/p) and nooglutyl (25–100 mg/kg, i/p). Complexes immobilized on the sulfated arabinogalactan were ineffective. |
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| ISSN: | 2218-7332 2658-3348 |