Treatment of Cancer Pain by Targeting Cytokines
Inflammation is one of the most important causes of the majority of cancer symptoms, including pain, fatigue, cachexia, and anorexia. Cancer pain affects 17 million people worldwide and can be caused by different mediators which act in primary efferent neurons directly or indirectly. Cytokines can b...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/984570 |
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| _version_ | 1849403624408481792 |
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| author | I. Vendrell D. Macedo I. Alho M. R. Dionísio L. Costa |
| author_facet | I. Vendrell D. Macedo I. Alho M. R. Dionísio L. Costa |
| author_sort | I. Vendrell |
| collection | DOAJ |
| description | Inflammation is one of the most important causes of the majority of cancer symptoms, including pain, fatigue, cachexia, and anorexia. Cancer pain affects 17 million people worldwide and can be caused by different mediators which act in primary efferent neurons directly or indirectly. Cytokines can be aberrantly produced by cancer and immune system cells and are of particular relevance in pain. Currently, there are very few strategies to control the release of cytokines that seems to be related to cancer pain. Nevertheless, in some cases, targeted drugs are available and in use for other diseases. In this paper, we aim to review the importance of cytokines in cancer pain and targeted strategies that can have an impact on controlling this symptom. |
| format | Article |
| id | doaj-art-84ee2cbe8ea24288b271bf4b043e853c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-84ee2cbe8ea24288b271bf4b043e853c2025-08-20T03:37:12ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/984570984570Treatment of Cancer Pain by Targeting CytokinesI. Vendrell0D. Macedo1I. Alho2M. R. Dionísio3L. Costa4Medical Oncology Department, Santa Maria Hospital, Northern Lisbon Hospital Center, Avenida Professor Egas Moniz, 1649-035 Lisbon, PortugalMedical Oncology Department, Santa Maria Hospital, Northern Lisbon Hospital Center, Avenida Professor Egas Moniz, 1649-035 Lisbon, PortugalCosta Lab, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-035 Lisboa, PortugalMedical Oncology Department, Santa Maria Hospital, Northern Lisbon Hospital Center, Avenida Professor Egas Moniz, 1649-035 Lisbon, PortugalMedical Oncology Department, Santa Maria Hospital, Northern Lisbon Hospital Center, Avenida Professor Egas Moniz, 1649-035 Lisbon, PortugalInflammation is one of the most important causes of the majority of cancer symptoms, including pain, fatigue, cachexia, and anorexia. Cancer pain affects 17 million people worldwide and can be caused by different mediators which act in primary efferent neurons directly or indirectly. Cytokines can be aberrantly produced by cancer and immune system cells and are of particular relevance in pain. Currently, there are very few strategies to control the release of cytokines that seems to be related to cancer pain. Nevertheless, in some cases, targeted drugs are available and in use for other diseases. In this paper, we aim to review the importance of cytokines in cancer pain and targeted strategies that can have an impact on controlling this symptom.http://dx.doi.org/10.1155/2015/984570 |
| spellingShingle | I. Vendrell D. Macedo I. Alho M. R. Dionísio L. Costa Treatment of Cancer Pain by Targeting Cytokines Mediators of Inflammation |
| title | Treatment of Cancer Pain by Targeting Cytokines |
| title_full | Treatment of Cancer Pain by Targeting Cytokines |
| title_fullStr | Treatment of Cancer Pain by Targeting Cytokines |
| title_full_unstemmed | Treatment of Cancer Pain by Targeting Cytokines |
| title_short | Treatment of Cancer Pain by Targeting Cytokines |
| title_sort | treatment of cancer pain by targeting cytokines |
| url | http://dx.doi.org/10.1155/2015/984570 |
| work_keys_str_mv | AT ivendrell treatmentofcancerpainbytargetingcytokines AT dmacedo treatmentofcancerpainbytargetingcytokines AT ialho treatmentofcancerpainbytargetingcytokines AT mrdionisio treatmentofcancerpainbytargetingcytokines AT lcosta treatmentofcancerpainbytargetingcytokines |