Histopathologic Evaluation and Single-cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients With Inflammatory Bowel DiseaseSummary

Histopathologic Evaluation and Single-cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients With Inflammatory Bowel DiseaseSummary

Background & Aims: Total abdominal colectomy (TAC) with a staged ileal pouch-anal anastomosis (IPAA) is a common surgical treatment for ulcerative colitis (UC). However, a significant percentage of patients experience pouch failure, leading to morbidity. This retrospective case-control study...

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Bibliographic Details
Main Authors: Andrea D. Olivas, Paul Chak Mou Ngai, Emily Schahrer, Junjie Xing, Mobarakeh Ghadiri, Kinga S. Olortegui, John F. Cursio, Shintaro Akiyama, Eugene B. Chang, Le Shen, Konstantin Umanskiy, David T. Rubin, David Zemmour, Christopher R. Weber
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Histopathologic Features
IL-1β
IL-10
Ileal Pouch-Anal Anastomosis (IPAA)
Immunology
Inflammatory Bowel Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X25001043
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