Origin and evolution of HIV-1 subtype A6.
<h4>Background</h4>HIV outbreaks in the Former Soviet Union (FSU) countries were characterized by repeated transmission of the HIV variant AFSU, which is now classified as a distinct subtype A sub-subtype called A6. The current study used phylogenetic/phylodynamic and signature mutation...
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0260604&type=printable |
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| author | Syed Hani Abidi Lazzat Aibekova Salima Davlidova Aidana Amangeldiyeva Brian Foley Syed Ali |
| author_facet | Syed Hani Abidi Lazzat Aibekova Salima Davlidova Aidana Amangeldiyeva Brian Foley Syed Ali |
| author_sort | Syed Hani Abidi |
| collection | DOAJ |
| description | <h4>Background</h4>HIV outbreaks in the Former Soviet Union (FSU) countries were characterized by repeated transmission of the HIV variant AFSU, which is now classified as a distinct subtype A sub-subtype called A6. The current study used phylogenetic/phylodynamic and signature mutation analyses to determine likely evolutionary relationship between subtype A6 and other subtype A sub-subtypes.<h4>Methods</h4>For this study, an initial Maximum Likelihood phylogenetic analysis was performed using a total of 553 full-length, publicly available, reverse transcriptase sequences, from A1, A2, A3, A4, A5, and A6 sub-subtypes of subtype A. For phylogenetic clustering and signature mutation analysis, a total of 5961 and 3959 pol and env sequences, respectively, were used.<h4>Results</h4>Phylogenetic and signature mutation analysis showed that HIV-1 sub-subtype A6 likely originated from sub-subtype A1 of African origin. A6 and A1 pol and env genes shared several signature mutations that indicate genetic similarity between the two subtypes. For A6, tMRCA dated to 1975, 15 years later than that of A1.<h4>Conclusion</h4>The current study provides insights into the evolution and diversification of A6 in the backdrop of FSU countries and indicates that A6 in FSU countries evolved from A1 of African origin and is getting bridged outside the FSU region. |
| format | Article |
| id | doaj-art-84ea3c85531341ed8e6b8cbaa455d1b2 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-84ea3c85531341ed8e6b8cbaa455d1b22025-08-20T02:17:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011612e026060410.1371/journal.pone.0260604Origin and evolution of HIV-1 subtype A6.Syed Hani AbidiLazzat AibekovaSalima DavlidovaAidana AmangeldiyevaBrian FoleySyed Ali<h4>Background</h4>HIV outbreaks in the Former Soviet Union (FSU) countries were characterized by repeated transmission of the HIV variant AFSU, which is now classified as a distinct subtype A sub-subtype called A6. The current study used phylogenetic/phylodynamic and signature mutation analyses to determine likely evolutionary relationship between subtype A6 and other subtype A sub-subtypes.<h4>Methods</h4>For this study, an initial Maximum Likelihood phylogenetic analysis was performed using a total of 553 full-length, publicly available, reverse transcriptase sequences, from A1, A2, A3, A4, A5, and A6 sub-subtypes of subtype A. For phylogenetic clustering and signature mutation analysis, a total of 5961 and 3959 pol and env sequences, respectively, were used.<h4>Results</h4>Phylogenetic and signature mutation analysis showed that HIV-1 sub-subtype A6 likely originated from sub-subtype A1 of African origin. A6 and A1 pol and env genes shared several signature mutations that indicate genetic similarity between the two subtypes. For A6, tMRCA dated to 1975, 15 years later than that of A1.<h4>Conclusion</h4>The current study provides insights into the evolution and diversification of A6 in the backdrop of FSU countries and indicates that A6 in FSU countries evolved from A1 of African origin and is getting bridged outside the FSU region.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0260604&type=printable |
| spellingShingle | Syed Hani Abidi Lazzat Aibekova Salima Davlidova Aidana Amangeldiyeva Brian Foley Syed Ali Origin and evolution of HIV-1 subtype A6. PLoS ONE |
| title | Origin and evolution of HIV-1 subtype A6. |
| title_full | Origin and evolution of HIV-1 subtype A6. |
| title_fullStr | Origin and evolution of HIV-1 subtype A6. |
| title_full_unstemmed | Origin and evolution of HIV-1 subtype A6. |
| title_short | Origin and evolution of HIV-1 subtype A6. |
| title_sort | origin and evolution of hiv 1 subtype a6 |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0260604&type=printable |
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