Pyroptosis‐Inducing Platinum(IV) Prodrugs via GSDME Pathway for Chemoimmunotherapy and Metastasis Inhibition in Triple‐Negative Breast Cancer

Pyroptosis‐Inducing Platinum(IV) Prodrugs via GSDME Pathway for Chemoimmunotherapy and Metastasis Inhibition in Triple‐Negative Breast Cancer

Abstract Pyroptosis has attracted significant attention for its role in cancer chemotherapy and immunotherapy. However, few drugs have been reported to induce pyroptosis via the Caspase‐3/gasdermin E (GSDME) pathway. Herein, three novel PtIV prodrugs, MRP, DRP, and HRP are rationally designed by con...

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Bibliographic Details
Main Authors: Xinda Yang, Chuansheng Xu, Youliang Zeng, Chunhui Wang, Yan Gao, Jie Ding, Sirui Chen, Yuheng Pan, Xin Zhang, Zongwan Mao, Shuo Shi
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
caspase‐3 cleaving GSDME
chemoimmunotherapy
metastasis inhibition
prodrugs
pyroptosis
Online Access:https://doi.org/10.1002/advs.202505567
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