Mechanical Properties of Membranes of Poly(L-co-DL-lactic acid) with Poly(caprolactone triol) and Study In Vivo
There is increasing interest in aliphatic polyesters from lactones and lactides because of their biodegradability and biocompatibility. Among these compounds, poly(lactide), and poly(glycolide), poly(ε-caprolactone) and their copolymers are especially interesting because of their potential applicati...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2014/541413 |
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| author | Marcia Adriana Tomaz Duarte Adriana Cristina Motta Eliana Aparecida de Rezende Duek |
| author_facet | Marcia Adriana Tomaz Duarte Adriana Cristina Motta Eliana Aparecida de Rezende Duek |
| author_sort | Marcia Adriana Tomaz Duarte |
| collection | DOAJ |
| description | There is increasing interest in aliphatic polyesters from lactones and lactides because of their biodegradability and biocompatibility. Among these compounds, poly(lactide), and poly(glycolide), poly(ε-caprolactone) and their copolymers are especially interesting because of their potential applications as biomedical materials. The aim of this study was to examine the properties of membranes of poly(L-co-D,L lactic acid) (PLDLA) with poly(caprolactone triol) (PCL-T) obtained by solvent evaporation. The blends were characterized by differential scanning calorimetry, dynamic mechanical analysis, Fourier transform infrared spectroscopy, and tensile strength tests. Based on the results of in vitro studies, PLDLA/PCL-T blends of 100/0 and 90/10 were implanted in subcutaneous tissue of Wistar rats for 1, 3, 7, 15, and 60 days to evaluate their biocompatibility. Histological analysis indicated that, although PCL-T-containing membranes caused a more prominent inflammatory reaction in the initial time intervals, by 60 days after implantation, the material was surrounded by dense, organized collagen with almost no inflammatory infiltrate. |
| format | Article |
| id | doaj-art-84e10a0b9c7f4ee5aa1acc02cac58456 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-84e10a0b9c7f4ee5aa1acc02cac584562025-02-03T01:28:05ZengWileyInternational Journal of Polymer Science1687-94221687-94302014-01-01201410.1155/2014/541413541413Mechanical Properties of Membranes of Poly(L-co-DL-lactic acid) with Poly(caprolactone triol) and Study In VivoMarcia Adriana Tomaz Duarte0Adriana Cristina Motta1Eliana Aparecida de Rezende Duek2Department of Physiological Sciences, Faculty of Medical Sciences, Pontifical Catholic University of São Paulo (PUC-SP), 18030-095 Sorocaba, SP, BrazilDepartment of Physiological Sciences, Faculty of Medical Sciences, Pontifical Catholic University of São Paulo (PUC-SP), 18030-095 Sorocaba, SP, BrazilDepartment of Physiological Sciences, Faculty of Medical Sciences, Pontifical Catholic University of São Paulo (PUC-SP), 18030-095 Sorocaba, SP, BrazilThere is increasing interest in aliphatic polyesters from lactones and lactides because of their biodegradability and biocompatibility. Among these compounds, poly(lactide), and poly(glycolide), poly(ε-caprolactone) and their copolymers are especially interesting because of their potential applications as biomedical materials. The aim of this study was to examine the properties of membranes of poly(L-co-D,L lactic acid) (PLDLA) with poly(caprolactone triol) (PCL-T) obtained by solvent evaporation. The blends were characterized by differential scanning calorimetry, dynamic mechanical analysis, Fourier transform infrared spectroscopy, and tensile strength tests. Based on the results of in vitro studies, PLDLA/PCL-T blends of 100/0 and 90/10 were implanted in subcutaneous tissue of Wistar rats for 1, 3, 7, 15, and 60 days to evaluate their biocompatibility. Histological analysis indicated that, although PCL-T-containing membranes caused a more prominent inflammatory reaction in the initial time intervals, by 60 days after implantation, the material was surrounded by dense, organized collagen with almost no inflammatory infiltrate.http://dx.doi.org/10.1155/2014/541413 |
| spellingShingle | Marcia Adriana Tomaz Duarte Adriana Cristina Motta Eliana Aparecida de Rezende Duek Mechanical Properties of Membranes of Poly(L-co-DL-lactic acid) with Poly(caprolactone triol) and Study In Vivo International Journal of Polymer Science |
| title | Mechanical Properties of Membranes of Poly(L-co-DL-lactic acid) with Poly(caprolactone triol) and Study In Vivo |
| title_full | Mechanical Properties of Membranes of Poly(L-co-DL-lactic acid) with Poly(caprolactone triol) and Study In Vivo |
| title_fullStr | Mechanical Properties of Membranes of Poly(L-co-DL-lactic acid) with Poly(caprolactone triol) and Study In Vivo |
| title_full_unstemmed | Mechanical Properties of Membranes of Poly(L-co-DL-lactic acid) with Poly(caprolactone triol) and Study In Vivo |
| title_short | Mechanical Properties of Membranes of Poly(L-co-DL-lactic acid) with Poly(caprolactone triol) and Study In Vivo |
| title_sort | mechanical properties of membranes of poly l co dl lactic acid with poly caprolactone triol and study in vivo |
| url | http://dx.doi.org/10.1155/2014/541413 |
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