Association between carotid artery hemodynamics and neurovascular coupling in cerebral small vessel disease: an exploratory study
BackgroundRecent studies have linked disrupted cerebral hemodynamics, including pulsatility index (PI) and wall shear stress (WSS), with neuroimaging features of cerebral small vessel disease (CSVD). Cerebral neurovascular coupling (NVC) dysfunction is an important pathophysiological mechanism of CS...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1536552/full |
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| author | Peng Zeng Bang Zeng Xiaohua Wang Feiyue Yin Binglan Li Lisha Nie Lin Tian Dan Luo Yongmei Li |
| author_facet | Peng Zeng Bang Zeng Xiaohua Wang Feiyue Yin Binglan Li Lisha Nie Lin Tian Dan Luo Yongmei Li |
| author_sort | Peng Zeng |
| collection | DOAJ |
| description | BackgroundRecent studies have linked disrupted cerebral hemodynamics, including pulsatility index (PI) and wall shear stress (WSS), with neuroimaging features of cerebral small vessel disease (CSVD). Cerebral neurovascular coupling (NVC) dysfunction is an important pathophysiological mechanism of CSVD. However, evidence linking the features of carotid artery hemodynamics to cerebral NVC is still lacking.ObjectiveThis study is aimed to explore the impact of PI and WSS on NVC and cognitive performance in CSVD patients using neuroimaging.MethodsThis study included 52 CSVD patients and 41 healthy controls. Carotid artery PI and WSS were measured using 4D flow magnetic resonance imaging (MRI). NVC was assessed through voxel-wise correlations between cerebral blood flow and the amplitude of low-frequency fluctuations. Multiple linear regression was used to investigate correlations between them.ResultsCSVD patients showed elevated PI in the C2 and C4 segments of the internal carotid artery and reduced WSS in the common carotid artery compared to controls. NVC measurements were significantly diminished in CSVD patients. Multiple linear regression analysis indicated significant correlations between reduced WSS and impaired NVC as well as between reduced PI and impaired NVC, but not between PI, WSS, and cognitive scores.ConclusionReduced WSS and PI in CSVD patients are associated with impaired NVC. These findings provide insights into the mechanisms underlying CSVD and suggest that hemodynamic abnormalities may serve as indicators of neurovascular dysfunction in early-stage CSVD. |
| format | Article |
| id | doaj-art-84d814ca5a1b442e93baddabf513f0c5 |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-84d814ca5a1b442e93baddabf513f0c52025-02-07T06:49:57ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-02-011710.3389/fnagi.2025.15365521536552Association between carotid artery hemodynamics and neurovascular coupling in cerebral small vessel disease: an exploratory studyPeng Zeng0Bang Zeng1Xiaohua Wang2Feiyue Yin3Binglan Li4Lisha Nie5Lin Tian6Dan Luo7Yongmei Li8Department of Radiology, First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Radiology, First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Radiology, First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Radiology, First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Radiology, First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaMRI Research, GE Healthcare (China), Beijing, ChinaCircle Cardiovascular Imaging, CVI Clinical Application China, Shanghai, ChinaDepartment of Radiology, First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Radiology, First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaBackgroundRecent studies have linked disrupted cerebral hemodynamics, including pulsatility index (PI) and wall shear stress (WSS), with neuroimaging features of cerebral small vessel disease (CSVD). Cerebral neurovascular coupling (NVC) dysfunction is an important pathophysiological mechanism of CSVD. However, evidence linking the features of carotid artery hemodynamics to cerebral NVC is still lacking.ObjectiveThis study is aimed to explore the impact of PI and WSS on NVC and cognitive performance in CSVD patients using neuroimaging.MethodsThis study included 52 CSVD patients and 41 healthy controls. Carotid artery PI and WSS were measured using 4D flow magnetic resonance imaging (MRI). NVC was assessed through voxel-wise correlations between cerebral blood flow and the amplitude of low-frequency fluctuations. Multiple linear regression was used to investigate correlations between them.ResultsCSVD patients showed elevated PI in the C2 and C4 segments of the internal carotid artery and reduced WSS in the common carotid artery compared to controls. NVC measurements were significantly diminished in CSVD patients. Multiple linear regression analysis indicated significant correlations between reduced WSS and impaired NVC as well as between reduced PI and impaired NVC, but not between PI, WSS, and cognitive scores.ConclusionReduced WSS and PI in CSVD patients are associated with impaired NVC. These findings provide insights into the mechanisms underlying CSVD and suggest that hemodynamic abnormalities may serve as indicators of neurovascular dysfunction in early-stage CSVD.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1536552/full4D flow MRIhemodynamicsresting-state functional MRImulti-delay arterial spin labelingneurovascular couplingcerebral small vessel disease |
| spellingShingle | Peng Zeng Bang Zeng Xiaohua Wang Feiyue Yin Binglan Li Lisha Nie Lin Tian Dan Luo Yongmei Li Association between carotid artery hemodynamics and neurovascular coupling in cerebral small vessel disease: an exploratory study Frontiers in Aging Neuroscience 4D flow MRI hemodynamics resting-state functional MRI multi-delay arterial spin labeling neurovascular coupling cerebral small vessel disease |
| title | Association between carotid artery hemodynamics and neurovascular coupling in cerebral small vessel disease: an exploratory study |
| title_full | Association between carotid artery hemodynamics and neurovascular coupling in cerebral small vessel disease: an exploratory study |
| title_fullStr | Association between carotid artery hemodynamics and neurovascular coupling in cerebral small vessel disease: an exploratory study |
| title_full_unstemmed | Association between carotid artery hemodynamics and neurovascular coupling in cerebral small vessel disease: an exploratory study |
| title_short | Association between carotid artery hemodynamics and neurovascular coupling in cerebral small vessel disease: an exploratory study |
| title_sort | association between carotid artery hemodynamics and neurovascular coupling in cerebral small vessel disease an exploratory study |
| topic | 4D flow MRI hemodynamics resting-state functional MRI multi-delay arterial spin labeling neurovascular coupling cerebral small vessel disease |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1536552/full |
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