Switching from Twice-Daily Basal Insulin Injections to Once-Daily Insulin Degludec Injection for Basal-Bolus Insulin Regimen in Japanese Patients with Type 1 Diabetes: A Pilot Study
The aim of this study was to investigate the efficacy of insulin degludec used for basal-bolus insulin regimen after switching from twice-daily basal insulin in Japanese patients with type 1 diabetes mellitus. The subjects were 22 type 1 diabetes patients treated with basal-bolus insulin regimen wit...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/176261 |
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| author | Yuka Tosaka Akio Kanazawa Fuki Ikeda Mayu Iida Junko Sato Kazuhisa Matsumoto Toyoyoshi Uchida Yoshifumi Tamura Takeshi Ogihara Tomoya Mita Tomoaki Shimizu Hiromasa Goto Chie Ohmura Yoshio Fujitani Hirotaka Watada |
| author_facet | Yuka Tosaka Akio Kanazawa Fuki Ikeda Mayu Iida Junko Sato Kazuhisa Matsumoto Toyoyoshi Uchida Yoshifumi Tamura Takeshi Ogihara Tomoya Mita Tomoaki Shimizu Hiromasa Goto Chie Ohmura Yoshio Fujitani Hirotaka Watada |
| author_sort | Yuka Tosaka |
| collection | DOAJ |
| description | The aim of this study was to investigate the efficacy of insulin degludec used for basal-bolus insulin regimen after switching from twice-daily basal insulin in Japanese patients with type 1 diabetes mellitus. The subjects were 22 type 1 diabetes patients treated with basal-bolus insulin regimen with twice-daily basal insulin. Basal insulin was switched to once-daily injection of insulin degludec with 10% dose reduction. HbA1c and fasting plasma glucose (FPG) were measured before and 12 weeks after switching. The frequency of hypoglycemic episodes, standard deviation (SD) of blood glucose, and mean of daily difference (MODD) were evaluated by continuous glucose monitoring (CGM) before and 4 weeks after switching. HbA1c and FPG before and 12 weeks after switching were comparable (HbA1c 8.5 ± 1.4 versus 8.7 ± 1.6%, P=0.28; FPG 203.2 ± 81.2 versus 206.5 ± 122.4 mg/dL, P=0.91). The frequency of hypoglycemia during nighttime was not significantly different at 4 weeks after switching (14.4 ± 17.0 versus 11.1 ± 15.0%, P=0.45). In addition, SD and MODD before and 4 weeks after switching were also comparable. In conclusion, glycemic control under once-daily insulin degludec injection was almost comparable to that under twice-daily basal insulin injections in Japanese type 1 diabetes patients. This study was registered with ID: UMIN000010474. |
| format | Article |
| id | doaj-art-84ca51962aa046b8a6427374f7c8e564 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-84ca51962aa046b8a6427374f7c8e5642025-08-20T02:08:39ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/176261176261Switching from Twice-Daily Basal Insulin Injections to Once-Daily Insulin Degludec Injection for Basal-Bolus Insulin Regimen in Japanese Patients with Type 1 Diabetes: A Pilot StudyYuka Tosaka0Akio Kanazawa1Fuki Ikeda2Mayu Iida3Junko Sato4Kazuhisa Matsumoto5Toyoyoshi Uchida6Yoshifumi Tamura7Takeshi Ogihara8Tomoya Mita9Tomoaki Shimizu10Hiromasa Goto11Chie Ohmura12Yoshio Fujitani13Hirotaka Watada14Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, JapanDepartment of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, JapanDepartment of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, JapanDepartment of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, JapanDepartment of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, JapanDepartment of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, JapanDepartment of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, JapanDepartment of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, JapanDepartment of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, JapanDepartment of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, JapanDepartment of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, JapanDepartment of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, JapanDepartment of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, JapanDepartment of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, JapanDepartment of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyou-ku, Tokyo 113-8421, JapanThe aim of this study was to investigate the efficacy of insulin degludec used for basal-bolus insulin regimen after switching from twice-daily basal insulin in Japanese patients with type 1 diabetes mellitus. The subjects were 22 type 1 diabetes patients treated with basal-bolus insulin regimen with twice-daily basal insulin. Basal insulin was switched to once-daily injection of insulin degludec with 10% dose reduction. HbA1c and fasting plasma glucose (FPG) were measured before and 12 weeks after switching. The frequency of hypoglycemic episodes, standard deviation (SD) of blood glucose, and mean of daily difference (MODD) were evaluated by continuous glucose monitoring (CGM) before and 4 weeks after switching. HbA1c and FPG before and 12 weeks after switching were comparable (HbA1c 8.5 ± 1.4 versus 8.7 ± 1.6%, P=0.28; FPG 203.2 ± 81.2 versus 206.5 ± 122.4 mg/dL, P=0.91). The frequency of hypoglycemia during nighttime was not significantly different at 4 weeks after switching (14.4 ± 17.0 versus 11.1 ± 15.0%, P=0.45). In addition, SD and MODD before and 4 weeks after switching were also comparable. In conclusion, glycemic control under once-daily insulin degludec injection was almost comparable to that under twice-daily basal insulin injections in Japanese type 1 diabetes patients. This study was registered with ID: UMIN000010474.http://dx.doi.org/10.1155/2015/176261 |
| spellingShingle | Yuka Tosaka Akio Kanazawa Fuki Ikeda Mayu Iida Junko Sato Kazuhisa Matsumoto Toyoyoshi Uchida Yoshifumi Tamura Takeshi Ogihara Tomoya Mita Tomoaki Shimizu Hiromasa Goto Chie Ohmura Yoshio Fujitani Hirotaka Watada Switching from Twice-Daily Basal Insulin Injections to Once-Daily Insulin Degludec Injection for Basal-Bolus Insulin Regimen in Japanese Patients with Type 1 Diabetes: A Pilot Study International Journal of Endocrinology |
| title | Switching from Twice-Daily Basal Insulin Injections to Once-Daily Insulin Degludec Injection for Basal-Bolus Insulin Regimen in Japanese Patients with Type 1 Diabetes: A Pilot Study |
| title_full | Switching from Twice-Daily Basal Insulin Injections to Once-Daily Insulin Degludec Injection for Basal-Bolus Insulin Regimen in Japanese Patients with Type 1 Diabetes: A Pilot Study |
| title_fullStr | Switching from Twice-Daily Basal Insulin Injections to Once-Daily Insulin Degludec Injection for Basal-Bolus Insulin Regimen in Japanese Patients with Type 1 Diabetes: A Pilot Study |
| title_full_unstemmed | Switching from Twice-Daily Basal Insulin Injections to Once-Daily Insulin Degludec Injection for Basal-Bolus Insulin Regimen in Japanese Patients with Type 1 Diabetes: A Pilot Study |
| title_short | Switching from Twice-Daily Basal Insulin Injections to Once-Daily Insulin Degludec Injection for Basal-Bolus Insulin Regimen in Japanese Patients with Type 1 Diabetes: A Pilot Study |
| title_sort | switching from twice daily basal insulin injections to once daily insulin degludec injection for basal bolus insulin regimen in japanese patients with type 1 diabetes a pilot study |
| url | http://dx.doi.org/10.1155/2015/176261 |
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