The epidemiology of adolescents living with perinatally acquired HIV: A cross-region global cohort analysis.
<h4>Background</h4>Globally, the population of adolescents living with perinatally acquired HIV (APHs) continues to expand. In this study, we pooled data from observational pediatric HIV cohorts and cohort networks, allowing comparisons of adolescents with perinatally acquired HIV in &qu...
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| author | Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Global Cohort Collaboration Amy L Slogrove Michael Schomaker Mary-Ann Davies Paige Williams Suna Balkan Jihane Ben-Farhat Nancy Calles Kulkanya Chokephaibulkit Charlotte Duff Tanoh François Eboua Adeodata Kekitiinwa-Rukyalekere Nicola Maxwell Jorge Pinto George Seage Chloe A Teasdale Sebastian Wanless Josiane Warszawski Kara Wools-Kaloustian Marcel Yotebieng Venessa Timmerman Intira J Collins Ruth Goodall Colette Smith Kunjal Patel Mary Paul Diana Gibb Rachel Vreeman Elaine J Abrams Rohan Hazra Russell Van Dyke Linda-Gail Bekker Lynne Mofenson Marissa Vicari Shaffiq Essajee Martina Penazzato Gabriel Anabwani Edith Q Mohapi Peter N Kazembe Makhosazana Hlatshwayo Mwita Lumumba Tessa Goetghebuer Claire Thorne Luisa Galli Annemarie van Rossum Carlo Giaquinto Magdalena Marczynska Laura Marques Filipa Prata Luminita Ene Liubov Okhonskaia Pablo Rojo Claudia Fortuny Lars Naver Christoph Rudin Sophie Le Coeur Alla Volokha Vanessa Rouzier Regina Succi Annette Sohn Azar Kariminia Andrew Edmonds Patricia Lelo Samuel Ayaya Patricia Ongwen Laura F Jefferys Sam Phiri Mwangelwa Mubiana-Mbewe Shobna Sawry Lorna Renner Mariam Sylla Mark J Abzug Myron Levin James Oleske Miriam Chernoff Shirley Traite Murli Purswani Ellen G Chadwick Ali Judd Valériane Leroy |
| author_facet | Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Global Cohort Collaboration Amy L Slogrove Michael Schomaker Mary-Ann Davies Paige Williams Suna Balkan Jihane Ben-Farhat Nancy Calles Kulkanya Chokephaibulkit Charlotte Duff Tanoh François Eboua Adeodata Kekitiinwa-Rukyalekere Nicola Maxwell Jorge Pinto George Seage Chloe A Teasdale Sebastian Wanless Josiane Warszawski Kara Wools-Kaloustian Marcel Yotebieng Venessa Timmerman Intira J Collins Ruth Goodall Colette Smith Kunjal Patel Mary Paul Diana Gibb Rachel Vreeman Elaine J Abrams Rohan Hazra Russell Van Dyke Linda-Gail Bekker Lynne Mofenson Marissa Vicari Shaffiq Essajee Martina Penazzato Gabriel Anabwani Edith Q Mohapi Peter N Kazembe Makhosazana Hlatshwayo Mwita Lumumba Tessa Goetghebuer Claire Thorne Luisa Galli Annemarie van Rossum Carlo Giaquinto Magdalena Marczynska Laura Marques Filipa Prata Luminita Ene Liubov Okhonskaia Pablo Rojo Claudia Fortuny Lars Naver Christoph Rudin Sophie Le Coeur Alla Volokha Vanessa Rouzier Regina Succi Annette Sohn Azar Kariminia Andrew Edmonds Patricia Lelo Samuel Ayaya Patricia Ongwen Laura F Jefferys Sam Phiri Mwangelwa Mubiana-Mbewe Shobna Sawry Lorna Renner Mariam Sylla Mark J Abzug Myron Levin James Oleske Miriam Chernoff Shirley Traite Murli Purswani Ellen G Chadwick Ali Judd Valériane Leroy |
| author_sort | Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Global Cohort Collaboration |
| collection | DOAJ |
| description | <h4>Background</h4>Globally, the population of adolescents living with perinatally acquired HIV (APHs) continues to expand. In this study, we pooled data from observational pediatric HIV cohorts and cohort networks, allowing comparisons of adolescents with perinatally acquired HIV in "real-life" settings across multiple regions. We describe the geographic and temporal characteristics and mortality outcomes of APHs across multiple regions, including South America and the Caribbean, North America, Europe, sub-Saharan Africa, and South and Southeast Asia.<h4>Methods and findings</h4>Through the Collaborative Initiative for Paediatric HIV Education and Research (CIPHER), individual retrospective longitudinal data from 12 cohort networks were pooled. All children infected with HIV who entered care before age 10 years, were not known to have horizontally acquired HIV, and were followed up beyond age 10 years were included in this analysis conducted from May 2016 to January 2017. Our primary analysis describes patient and treatment characteristics of APHs at key time points, including first HIV-associated clinic visit, antiretroviral therapy (ART) start, age 10 years, and last visit, and compares these characteristics by geographic region, country income group (CIG), and birth period. Our secondary analysis describes mortality, transfer out, and lost to follow-up (LTFU) as outcomes at age 15 years, using competing risk analysis. Among the 38,187 APHs included, 51% were female, 79% were from sub-Saharan Africa and 65% lived in low-income countries. APHs from 51 countries were included (Europe: 14 countries and 3,054 APHs; North America: 1 country and 1,032 APHs; South America and the Caribbean: 4 countries and 903 APHs; South and Southeast Asia: 7 countries and 2,902 APHs; sub-Saharan Africa, 25 countries and 30,296 APHs). Observation started as early as 1982 in Europe and 1996 in sub-Saharan Africa, and continued until at least 2014 in all regions. The median (interquartile range [IQR]) duration of adolescent follow-up was 3.1 (1.5-5.2) years for the total cohort and 6.4 (3.6-8.0) years in Europe, 3.7 (2.0-5.4) years in North America, 2.5 (1.2-4.4) years in South and Southeast Asia, 5.0 (2.7-7.5) years in South America and the Caribbean, and 2.1 (0.9-3.8) years in sub-Saharan Africa. Median (IQR) age at first visit differed substantially by region, ranging from 0.7 (0.3-2.1) years in North America to 7.1 (5.3-8.6) years in sub-Saharan Africa. The median age at ART start varied from 0.9 (0.4-2.6) years in North America to 7.9 (6.0-9.3) years in sub-Saharan Africa. The cumulative incidence estimates (95% confidence interval [CI]) at age 15 years for mortality, transfers out, and LTFU for all APHs were 2.6% (2.4%-2.8%), 15.6% (15.1%-16.0%), and 11.3% (10.9%-11.8%), respectively. Mortality was lowest in Europe (0.8% [0.5%-1.1%]) and highest in South America and the Caribbean (4.4% [3.1%-6.1%]). However, LTFU was lowest in South America and the Caribbean (4.8% [3.4%-6.7%]) and highest in sub-Saharan Africa (13.2% [12.6%-13.7%]). Study limitations include the high LTFU rate in sub-Saharan Africa, which could have affected the comparison of mortality across regions; inclusion of data only for APHs receiving ART from some countries; and unavailability of data from high-burden countries such as Nigeria.<h4>Conclusion</h4>To our knowledge, our study represents the largest multiregional epidemiological analysis of APHs. Despite probable under-ascertained mortality, mortality in APHs remains substantially higher in sub-Saharan Africa, South and Southeast Asia, and South America and the Caribbean than in Europe. Collaborations such as CIPHER enable us to monitor current global temporal trends in outcomes over time to inform appropriate policy responses. |
| format | Article |
| id | doaj-art-84c71bfb1d04428fac3aac5e22be3e2c |
| institution | Kabale University |
| issn | 1549-1277 1549-1676 |
| language | English |
| publishDate | 2018-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Medicine |
| spelling | doaj-art-84c71bfb1d04428fac3aac5e22be3e2c2025-08-20T03:25:45ZengPublic Library of Science (PLoS)PLoS Medicine1549-12771549-16762018-03-01153e100251410.1371/journal.pmed.1002514The epidemiology of adolescents living with perinatally acquired HIV: A cross-region global cohort analysis.Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Global Cohort CollaborationAmy L SlogroveMichael SchomakerMary-Ann DaviesPaige WilliamsSuna BalkanJihane Ben-FarhatNancy CallesKulkanya ChokephaibulkitCharlotte DuffTanoh François EbouaAdeodata Kekitiinwa-RukyalekereNicola MaxwellJorge PintoGeorge SeageChloe A TeasdaleSebastian WanlessJosiane WarszawskiKara Wools-KaloustianMarcel YotebiengVenessa TimmermanIntira J CollinsRuth GoodallColette SmithKunjal PatelMary PaulDiana GibbRachel VreemanElaine J AbramsRohan HazraRussell Van DykeLinda-Gail BekkerLynne MofensonMarissa VicariShaffiq EssajeeMartina PenazzatoGabriel AnabwaniEdith Q MohapiPeter N KazembeMakhosazana HlatshwayoMwita LumumbaTessa GoetghebuerClaire ThorneLuisa GalliAnnemarie van RossumCarlo GiaquintoMagdalena MarczynskaLaura MarquesFilipa PrataLuminita EneLiubov OkhonskaiaPablo RojoClaudia FortunyLars NaverChristoph RudinSophie Le CoeurAlla VolokhaVanessa RouzierRegina SucciAnnette SohnAzar KariminiaAndrew EdmondsPatricia LeloSamuel AyayaPatricia OngwenLaura F JefferysSam PhiriMwangelwa Mubiana-MbeweShobna SawryLorna RennerMariam SyllaMark J AbzugMyron LevinJames OleskeMiriam ChernoffShirley TraiteMurli PurswaniEllen G ChadwickAli JuddValériane Leroy<h4>Background</h4>Globally, the population of adolescents living with perinatally acquired HIV (APHs) continues to expand. In this study, we pooled data from observational pediatric HIV cohorts and cohort networks, allowing comparisons of adolescents with perinatally acquired HIV in "real-life" settings across multiple regions. We describe the geographic and temporal characteristics and mortality outcomes of APHs across multiple regions, including South America and the Caribbean, North America, Europe, sub-Saharan Africa, and South and Southeast Asia.<h4>Methods and findings</h4>Through the Collaborative Initiative for Paediatric HIV Education and Research (CIPHER), individual retrospective longitudinal data from 12 cohort networks were pooled. All children infected with HIV who entered care before age 10 years, were not known to have horizontally acquired HIV, and were followed up beyond age 10 years were included in this analysis conducted from May 2016 to January 2017. Our primary analysis describes patient and treatment characteristics of APHs at key time points, including first HIV-associated clinic visit, antiretroviral therapy (ART) start, age 10 years, and last visit, and compares these characteristics by geographic region, country income group (CIG), and birth period. Our secondary analysis describes mortality, transfer out, and lost to follow-up (LTFU) as outcomes at age 15 years, using competing risk analysis. Among the 38,187 APHs included, 51% were female, 79% were from sub-Saharan Africa and 65% lived in low-income countries. APHs from 51 countries were included (Europe: 14 countries and 3,054 APHs; North America: 1 country and 1,032 APHs; South America and the Caribbean: 4 countries and 903 APHs; South and Southeast Asia: 7 countries and 2,902 APHs; sub-Saharan Africa, 25 countries and 30,296 APHs). Observation started as early as 1982 in Europe and 1996 in sub-Saharan Africa, and continued until at least 2014 in all regions. The median (interquartile range [IQR]) duration of adolescent follow-up was 3.1 (1.5-5.2) years for the total cohort and 6.4 (3.6-8.0) years in Europe, 3.7 (2.0-5.4) years in North America, 2.5 (1.2-4.4) years in South and Southeast Asia, 5.0 (2.7-7.5) years in South America and the Caribbean, and 2.1 (0.9-3.8) years in sub-Saharan Africa. Median (IQR) age at first visit differed substantially by region, ranging from 0.7 (0.3-2.1) years in North America to 7.1 (5.3-8.6) years in sub-Saharan Africa. The median age at ART start varied from 0.9 (0.4-2.6) years in North America to 7.9 (6.0-9.3) years in sub-Saharan Africa. The cumulative incidence estimates (95% confidence interval [CI]) at age 15 years for mortality, transfers out, and LTFU for all APHs were 2.6% (2.4%-2.8%), 15.6% (15.1%-16.0%), and 11.3% (10.9%-11.8%), respectively. Mortality was lowest in Europe (0.8% [0.5%-1.1%]) and highest in South America and the Caribbean (4.4% [3.1%-6.1%]). However, LTFU was lowest in South America and the Caribbean (4.8% [3.4%-6.7%]) and highest in sub-Saharan Africa (13.2% [12.6%-13.7%]). Study limitations include the high LTFU rate in sub-Saharan Africa, which could have affected the comparison of mortality across regions; inclusion of data only for APHs receiving ART from some countries; and unavailability of data from high-burden countries such as Nigeria.<h4>Conclusion</h4>To our knowledge, our study represents the largest multiregional epidemiological analysis of APHs. Despite probable under-ascertained mortality, mortality in APHs remains substantially higher in sub-Saharan Africa, South and Southeast Asia, and South America and the Caribbean than in Europe. Collaborations such as CIPHER enable us to monitor current global temporal trends in outcomes over time to inform appropriate policy responses.https://doi.org/10.1371/journal.pmed.1002514 |
| spellingShingle | Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Global Cohort Collaboration Amy L Slogrove Michael Schomaker Mary-Ann Davies Paige Williams Suna Balkan Jihane Ben-Farhat Nancy Calles Kulkanya Chokephaibulkit Charlotte Duff Tanoh François Eboua Adeodata Kekitiinwa-Rukyalekere Nicola Maxwell Jorge Pinto George Seage Chloe A Teasdale Sebastian Wanless Josiane Warszawski Kara Wools-Kaloustian Marcel Yotebieng Venessa Timmerman Intira J Collins Ruth Goodall Colette Smith Kunjal Patel Mary Paul Diana Gibb Rachel Vreeman Elaine J Abrams Rohan Hazra Russell Van Dyke Linda-Gail Bekker Lynne Mofenson Marissa Vicari Shaffiq Essajee Martina Penazzato Gabriel Anabwani Edith Q Mohapi Peter N Kazembe Makhosazana Hlatshwayo Mwita Lumumba Tessa Goetghebuer Claire Thorne Luisa Galli Annemarie van Rossum Carlo Giaquinto Magdalena Marczynska Laura Marques Filipa Prata Luminita Ene Liubov Okhonskaia Pablo Rojo Claudia Fortuny Lars Naver Christoph Rudin Sophie Le Coeur Alla Volokha Vanessa Rouzier Regina Succi Annette Sohn Azar Kariminia Andrew Edmonds Patricia Lelo Samuel Ayaya Patricia Ongwen Laura F Jefferys Sam Phiri Mwangelwa Mubiana-Mbewe Shobna Sawry Lorna Renner Mariam Sylla Mark J Abzug Myron Levin James Oleske Miriam Chernoff Shirley Traite Murli Purswani Ellen G Chadwick Ali Judd Valériane Leroy The epidemiology of adolescents living with perinatally acquired HIV: A cross-region global cohort analysis. PLoS Medicine |
| title | The epidemiology of adolescents living with perinatally acquired HIV: A cross-region global cohort analysis. |
| title_full | The epidemiology of adolescents living with perinatally acquired HIV: A cross-region global cohort analysis. |
| title_fullStr | The epidemiology of adolescents living with perinatally acquired HIV: A cross-region global cohort analysis. |
| title_full_unstemmed | The epidemiology of adolescents living with perinatally acquired HIV: A cross-region global cohort analysis. |
| title_short | The epidemiology of adolescents living with perinatally acquired HIV: A cross-region global cohort analysis. |
| title_sort | epidemiology of adolescents living with perinatally acquired hiv a cross region global cohort analysis |
| url | https://doi.org/10.1371/journal.pmed.1002514 |
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epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT annemarievanrossum epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT carlogiaquinto epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT magdalenamarczynska epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT lauramarques epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT filipaprata epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT luminitaene epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT liubovokhonskaia epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT pablorojo epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT claudiafortuny 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epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT patricialelo epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT samuelayaya epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT patriciaongwen epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT laurafjefferys epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT samphiri epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT mwangelwamubianambewe epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT shobnasawry epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT lornarenner epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT mariamsylla epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT markjabzug epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT myronlevin epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT jamesoleske epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT miriamchernoff epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT shirleytraite epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT murlipurswani epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT ellengchadwick epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT alijudd epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis AT valerianeleroy epidemiologyofadolescentslivingwithperinatallyacquiredhivacrossregionglobalcohortanalysis |