The determination of effects of in ovo administrated bisphenol a on the development of thymus and proportion of alpha-naphthyl acetate esterase enzyme lymphocyte by using histological and enzymehistochemical methods in chicken
<b>Aim:</b> The aim of this study is to the determination of effects of in ovo administrated Bisphenol A on the development of thymus and proportion of alpha-naphthyl acetate esterase enzyme lymphocyte by using histological and enzyme histochemical methods in chicken.<p> <b>M...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1256 |
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| Summary: | <b>Aim:</b> The aim of this study is to the determination of effects
of in ovo administrated Bisphenol A on the development of
thymus and proportion of alpha-naphthyl acetate esterase
enzyme lymphocyte by using histological and enzyme histochemical
methods in chicken.<p>
<b>Materials and Methods:</b> For this purpose, 310 fertile eggs,
weighed 50-50 g, of Isa Brown laying parent stock were divided
into 5 groups as control, vehicle- control , 50 100, and
250 μg/egg BPA. Test solutions were injected into yolk before
incubation. At the 13th, 18th and 21st days of incubation,
10 eggs were opened from each group and blood and thymus
tissue samples were taken from the obtained embryos.<p>
<b>Results:</b> On the 13th, 18th and 21st days of incubation, BPAtreated
groups were found to be retarded embryonic development
of thymus tissue compared to the control group. At
the same time, in BPA-treated groups, lymphoid tissue had
less cell density and the number of ANAE positive lymphocytes
decreased. The percentage of peripheral blood ANAE positive
lymphocytes was significantly lower in the BPA-treated
groups than in the control groups (p <0.05).<p>
<b>Conclusion:</b> It has been found that BPA inhibits embryonic
development of thymus, decreases ANAE positive lymphocyte
rate. It was concluded that significant disturbances in the
immune system function of the affected animals might be
occured and regulation on the use of BPA should be revised. |
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| ISSN: | 1309-6958 2146-1953 |