Detection of intracranial hypertension in children using optical coherence tomography: a systematic review
Objectives To evaluate the diagnostic capability of optical coherence tomography (OCT) in children aged under 18 years old with intracranial hypertension (IH).Design Systematic review.Methods We conducted a systematic review using the following platforms to search the keywords ‘optical coherence tom...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2021-08-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/11/8/e046935.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850169437032808448 |
|---|---|
| author | Michael Hisaund Sohaib R Rufai Noor ul Owase Jeelani Rebecca J McLean |
| author_facet | Michael Hisaund Sohaib R Rufai Noor ul Owase Jeelani Rebecca J McLean |
| author_sort | Michael Hisaund |
| collection | DOAJ |
| description | Objectives To evaluate the diagnostic capability of optical coherence tomography (OCT) in children aged under 18 years old with intracranial hypertension (IH).Design Systematic review.Methods We conducted a systematic review using the following platforms to search the keywords ‘optical coherence tomography’ and ‘intracranial hypertension’ from inception to 2 April 2020: Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, PubMed and Web of Science, without language restrictions. Our search returned 2729 records, screened by two independent screeners. Studies were graded according to the Oxford Centre for Evidence-Based Medicine and National Institutes of Health Quality Assessment Tool for observational studies.Results Twenty-one studies were included. Conditions included craniosynostosis (n=354 patients), idiopathic IH (IIH; n=102), space-occupying lesion (SOL; n=42) and other pathology (n=29). OCT measures included optic nerve parameters, rim parameters (notably retinal nerve fibre layer thickness) and retinal parameters. Levels of evidence included 2b (n=13 studies), 3b (n=4) and 4 (n=4). Quality of 10 studies was fair and 11 poor. There was inconsistency in OCT parameters and reference measures studied, although OCT did demonstrate good diagnostic capability for IH in craniosynostosis, IIH and SOL.Conclusions This systematic review identified various studies involving OCT to assist diagnosis and management of IH in children with craniosynostosis, IIH, SOL and other pathology, in conjunction with established clinical measures of intracranial pressure. However, no level 1 evidence was identified. Validating prospective studies are, therefore, required to determine optimal OCT parameters in this role and to develop formal clinical guidelines.PROSPERO registration number CRD42019154254. |
| format | Article |
| id | doaj-art-84c5a3f294764e5dbc92b800a0e9ce91 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-84c5a3f294764e5dbc92b800a0e9ce912025-08-20T02:20:44ZengBMJ Publishing GroupBMJ Open2044-60552021-08-0111810.1136/bmjopen-2020-046935Detection of intracranial hypertension in children using optical coherence tomography: a systematic reviewMichael Hisaund0Sohaib R Rufai1Noor ul Owase Jeelani2Rebecca J McLean3University of Leicester Ulverscroft Eye Unit, Leicester Royal Infirmary, Leicester, UK4 Ulverscroft Eye Unit, University of Leicester, Leicester, Leicestershire, UKCraniofacial Unit, Great Ormond Street Hospital for Children, London, United KingdomUlverscroft Eye Unit, University of Leicester, Leicester, UKObjectives To evaluate the diagnostic capability of optical coherence tomography (OCT) in children aged under 18 years old with intracranial hypertension (IH).Design Systematic review.Methods We conducted a systematic review using the following platforms to search the keywords ‘optical coherence tomography’ and ‘intracranial hypertension’ from inception to 2 April 2020: Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, PubMed and Web of Science, without language restrictions. Our search returned 2729 records, screened by two independent screeners. Studies were graded according to the Oxford Centre for Evidence-Based Medicine and National Institutes of Health Quality Assessment Tool for observational studies.Results Twenty-one studies were included. Conditions included craniosynostosis (n=354 patients), idiopathic IH (IIH; n=102), space-occupying lesion (SOL; n=42) and other pathology (n=29). OCT measures included optic nerve parameters, rim parameters (notably retinal nerve fibre layer thickness) and retinal parameters. Levels of evidence included 2b (n=13 studies), 3b (n=4) and 4 (n=4). Quality of 10 studies was fair and 11 poor. There was inconsistency in OCT parameters and reference measures studied, although OCT did demonstrate good diagnostic capability for IH in craniosynostosis, IIH and SOL.Conclusions This systematic review identified various studies involving OCT to assist diagnosis and management of IH in children with craniosynostosis, IIH, SOL and other pathology, in conjunction with established clinical measures of intracranial pressure. However, no level 1 evidence was identified. Validating prospective studies are, therefore, required to determine optimal OCT parameters in this role and to develop formal clinical guidelines.PROSPERO registration number CRD42019154254.https://bmjopen.bmj.com/content/11/8/e046935.full |
| spellingShingle | Michael Hisaund Sohaib R Rufai Noor ul Owase Jeelani Rebecca J McLean Detection of intracranial hypertension in children using optical coherence tomography: a systematic review BMJ Open |
| title | Detection of intracranial hypertension in children using optical coherence tomography: a systematic review |
| title_full | Detection of intracranial hypertension in children using optical coherence tomography: a systematic review |
| title_fullStr | Detection of intracranial hypertension in children using optical coherence tomography: a systematic review |
| title_full_unstemmed | Detection of intracranial hypertension in children using optical coherence tomography: a systematic review |
| title_short | Detection of intracranial hypertension in children using optical coherence tomography: a systematic review |
| title_sort | detection of intracranial hypertension in children using optical coherence tomography a systematic review |
| url | https://bmjopen.bmj.com/content/11/8/e046935.full |
| work_keys_str_mv | AT michaelhisaund detectionofintracranialhypertensioninchildrenusingopticalcoherencetomographyasystematicreview AT sohaibrrufai detectionofintracranialhypertensioninchildrenusingopticalcoherencetomographyasystematicreview AT noorulowasejeelani detectionofintracranialhypertensioninchildrenusingopticalcoherencetomographyasystematicreview AT rebeccajmclean detectionofintracranialhypertensioninchildrenusingopticalcoherencetomographyasystematicreview |