The need for novel influenza vaccines in low- and middle-income countries: A narrative review
Influenza viruses cause 3–5 million severe cases and 300,000–600,000 deaths worldwide. Most of the disease burden is in Low- and Middle-Income Countries (LMICs) owing to factors such as high population density, infrastructure challenges, poor quality healthcare, lack of consistent recommendations, l...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Brazilian Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867024007487 |
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| author | Julia R. Spinardi Karan B. Thakkar Verna L. Welch Oladayo Jagun Moe H. Kyaw |
| author_facet | Julia R. Spinardi Karan B. Thakkar Verna L. Welch Oladayo Jagun Moe H. Kyaw |
| author_sort | Julia R. Spinardi |
| collection | DOAJ |
| description | Influenza viruses cause 3–5 million severe cases and 300,000–600,000 deaths worldwide. Most of the disease burden is in Low- and Middle-Income Countries (LMICs) owing to factors such as high population density, infrastructure challenges, poor quality healthcare, lack of consistent recommendations, less prioritization of all high-risk groups, and prevalent use of trivalent influenza vaccines. Although influenza vaccines are effective in reducing the annual influenza disease burden, existing vaccines have several limitations. In this narrative review, we address the unmet needs of existing influenza vaccines in LMICs in Africa, Asia Pacific, Latin America and the Middle East and discuss the characteristics of novel vaccines in clinical development. We also describe features of a successful vaccination program that LMICs could emulate to improve their current vaccination coverage and reduce the public health burden of influenza. |
| format | Article |
| id | doaj-art-84bf434aee0f4e05907d949db96266f6 |
| institution | Kabale University |
| issn | 1413-8670 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj-art-84bf434aee0f4e05907d949db96266f62025-01-26T05:03:33ZengElsevierBrazilian Journal of Infectious Diseases1413-86702025-01-01291104465The need for novel influenza vaccines in low- and middle-income countries: A narrative reviewJulia R. Spinardi0Karan B. Thakkar1Verna L. Welch2Oladayo Jagun3Moe H. Kyaw4Vaccine Medical and Scientific Affairs, Emerging Markets, Pfizer Inc., São Paulo, SP, Brazil; Corresponding author.Vaccine Medical and Scientific Affairs, Emerging Markets, Pfizer Inc., Singapore, SingaporeVaccine Medical and Scientific Affairs, Pfizer Inc., Pennsylvania, USAReal World Strategy and Innovation, IQVIA Inc., New Jersey, USAVaccine Medical and Scientific Affairs, Emerging Markets, Pfizer Inc., Virginia, USAInfluenza viruses cause 3–5 million severe cases and 300,000–600,000 deaths worldwide. Most of the disease burden is in Low- and Middle-Income Countries (LMICs) owing to factors such as high population density, infrastructure challenges, poor quality healthcare, lack of consistent recommendations, less prioritization of all high-risk groups, and prevalent use of trivalent influenza vaccines. Although influenza vaccines are effective in reducing the annual influenza disease burden, existing vaccines have several limitations. In this narrative review, we address the unmet needs of existing influenza vaccines in LMICs in Africa, Asia Pacific, Latin America and the Middle East and discuss the characteristics of novel vaccines in clinical development. We also describe features of a successful vaccination program that LMICs could emulate to improve their current vaccination coverage and reduce the public health burden of influenza.http://www.sciencedirect.com/science/article/pii/S1413867024007487InfluenzaImmunizationPublic healthDisease burdenLow- and middle-income countries |
| spellingShingle | Julia R. Spinardi Karan B. Thakkar Verna L. Welch Oladayo Jagun Moe H. Kyaw The need for novel influenza vaccines in low- and middle-income countries: A narrative review Brazilian Journal of Infectious Diseases Influenza Immunization Public health Disease burden Low- and middle-income countries |
| title | The need for novel influenza vaccines in low- and middle-income countries: A narrative review |
| title_full | The need for novel influenza vaccines in low- and middle-income countries: A narrative review |
| title_fullStr | The need for novel influenza vaccines in low- and middle-income countries: A narrative review |
| title_full_unstemmed | The need for novel influenza vaccines in low- and middle-income countries: A narrative review |
| title_short | The need for novel influenza vaccines in low- and middle-income countries: A narrative review |
| title_sort | need for novel influenza vaccines in low and middle income countries a narrative review |
| topic | Influenza Immunization Public health Disease burden Low- and middle-income countries |
| url | http://www.sciencedirect.com/science/article/pii/S1413867024007487 |
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