The CoREST complex is a therapeutic vulnerability in malignant peripheral nerve sheath tumors

The CoREST complex is a therapeutic vulnerability in malignant peripheral nerve sheath tumors

Abstract Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive sarcoma that may be seen in patients with neurofibromatosis type 1 (NF1) or occur sporadically. While surgery is the primary treatment for localized MPNST with a 61.9% overall survival rate, metastatic disease is often f...

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Bibliographic Details
Main Authors: Imad Soukar, Robert J. Fisher, Sanjana Bhagavatula, Marianne Collard, Philip A. Cole, Rhoda M. Alani
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
CoREST
Corin
HDAC
LSD1
MPNST
Epigenetics
Online Access:https://doi.org/10.1038/s41598-025-94517-w
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