Reevaluating BED in cervical cancer HDR brachytherapy: source decay and tissue-specific repair significantly impact radiobiological dose

Reevaluating BED in cervical cancer HDR brachytherapy: source decay and tissue-specific repair significantly impact radiobiological dose

ObjectiveThis study aims to investigate the influence of intrafraction DNA damage repair on biologically effective dose (BED) in Ir-192 high-dose-rate (HDR) brachytherapy (BT) for cervical cancer. Specifically, we examine BED variations resulting from source decay at various treatment time points ac...

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Bibliographic Details
Main Authors: Suyan Bi, Jiaomei Zhou, Meiling Xu, Zhitao Dai
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
high-dose-rate brachytherapy (HDR BT)
cervical cancer
source decay impact
tumor cell lines
intrafraction damage repair
biological effective dose (BED)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1407606/full
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