Multimodal single cell-resolved spatial proteomics reveal pancreatic tumor heterogeneity

Multimodal single cell-resolved spatial proteomics reveal pancreatic tumor heterogeneity

Abstract Despite the advances in antibody-guided cell typing and mass spectrometry-based proteomics, their integration is hindered by challenges for processing rare cells in the heterogeneous tissue context. Here, we introduce Spatial and Cell-type Proteomics (SCPro), which combines multiplexed imag...

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Main Authors: Yanfen Xu, Xi Wang, Yuan Li, Yiheng Mao, Yiran Su, Yize Mao, Yun Yang, Weina Gao, Changying Fu, Wendong Chen, Xueting Ye, Fuchao Liang, Panzhu Bai, Ying Sun, Shengping Li, Ruilian Xu, Ruijun Tian
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54438-0
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