A systematic analysis of the network of lncRNAs and mRNAs regulated by TP53 and TP53 mutants with hotspot mutations

A systematic analysis of the network of lncRNAs and mRNAs regulated by TP53 and TP53 mutants with hotspot mutations

Abstract The transcription factor TP53 exhibits the preeminent frequency of genetic mutations across various cancer types. Long non-coding RNAs (lncRNAs) stand as pivotal molecules in the initiation and progression of carcinogenesis. Nonetheless, the specific roles of TP53-regulated lncRNAs in colon...

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Main Authors: Hong Chen, Zhongrong Guo, Peilong Li, Wanxiang Liao, Yunhao Li, Bo Li, Yan Li, Qingqing Zhu, Yingsi Lu, Lifen Huang, Xiaoyu Xu, Yunjun Xiao, Chengming Zhu, Song He, Guoxing Zheng
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-12522-5
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