Effect of ethnicity on HbA1c levels in individuals without diabetes: Systematic review and meta-analysis.
<h4>Aims/hypothesis</h4>Disparities in HbA1c levels have been observed among ethnic groups. Most studies were performed in patients with diabetes mellitus (DM), which may interfere with results due to the high variability of glucose levels. We conducted a systematic review and meta-analy...
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0171315 |
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| author | Gabriela Cavagnolli Ana Laura Pimentel Priscila Aparecida Correa Freitas Jorge Luiz Gross Joíza Lins Camargo |
| author_facet | Gabriela Cavagnolli Ana Laura Pimentel Priscila Aparecida Correa Freitas Jorge Luiz Gross Joíza Lins Camargo |
| author_sort | Gabriela Cavagnolli |
| collection | DOAJ |
| description | <h4>Aims/hypothesis</h4>Disparities in HbA1c levels have been observed among ethnic groups. Most studies were performed in patients with diabetes mellitus (DM), which may interfere with results due to the high variability of glucose levels. We conducted a systematic review and meta-analysis to investigate the effect of ethnicity on HbA1c levels in individuals without DM.<h4>Methods</h4>This is a systematic review with meta-analysis. We searched MEDLINE and EMBASE up to September 2016. Studies published after 1996, performed in adults without DM, reporting HbA1c results measured by certified/standardized methods were included. A random effects model was used and the effect size was presented as weighted HbA1c mean difference (95% CI) between different ethnicities as compared to White ethnicity.<h4>Results</h4>Twelve studies met the inclusion criteria, totalling data from 49,238 individuals. There were significant differences between HbA1c levels in Blacks [0.26% (2.8 mmol/mol); 95% CI 0.18 to 0.33 (2.0 to 3.6), p <0.001; I2 = 90%, p <0.001], Asians [0.24% (2.6 mmol/mol); 95% CI 0.16 to 0.33 (1.7 to 3.6), p <0.001; I2 = 80%, p = 0.0006] and Latinos [0.08% (0.9 mmol/mol); IC 95% 0.06 to 0.10 (0.7 to 1.1); p <0.001; I2 = 0%; p = 0.72] when compared to Whites.<h4>Conclusions/interpretation</h4>This meta-analysis shows that, in individuals without DM, HbA1c values are higher in Blacks, Asians, and Latinos when compared to White persons. Although small, these differences might have impact on the use of a sole HbA1c point to diagnose DM in all ethnic populations. |
| format | Article |
| id | doaj-art-84aa4b56ebd1463786ef2c05ffd4ee3e |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-84aa4b56ebd1463786ef2c05ffd4ee3e2025-08-20T03:26:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01122e017131510.1371/journal.pone.0171315Effect of ethnicity on HbA1c levels in individuals without diabetes: Systematic review and meta-analysis.Gabriela CavagnolliAna Laura PimentelPriscila Aparecida Correa FreitasJorge Luiz GrossJoíza Lins Camargo<h4>Aims/hypothesis</h4>Disparities in HbA1c levels have been observed among ethnic groups. Most studies were performed in patients with diabetes mellitus (DM), which may interfere with results due to the high variability of glucose levels. We conducted a systematic review and meta-analysis to investigate the effect of ethnicity on HbA1c levels in individuals without DM.<h4>Methods</h4>This is a systematic review with meta-analysis. We searched MEDLINE and EMBASE up to September 2016. Studies published after 1996, performed in adults without DM, reporting HbA1c results measured by certified/standardized methods were included. A random effects model was used and the effect size was presented as weighted HbA1c mean difference (95% CI) between different ethnicities as compared to White ethnicity.<h4>Results</h4>Twelve studies met the inclusion criteria, totalling data from 49,238 individuals. There were significant differences between HbA1c levels in Blacks [0.26% (2.8 mmol/mol); 95% CI 0.18 to 0.33 (2.0 to 3.6), p <0.001; I2 = 90%, p <0.001], Asians [0.24% (2.6 mmol/mol); 95% CI 0.16 to 0.33 (1.7 to 3.6), p <0.001; I2 = 80%, p = 0.0006] and Latinos [0.08% (0.9 mmol/mol); IC 95% 0.06 to 0.10 (0.7 to 1.1); p <0.001; I2 = 0%; p = 0.72] when compared to Whites.<h4>Conclusions/interpretation</h4>This meta-analysis shows that, in individuals without DM, HbA1c values are higher in Blacks, Asians, and Latinos when compared to White persons. Although small, these differences might have impact on the use of a sole HbA1c point to diagnose DM in all ethnic populations.https://doi.org/10.1371/journal.pone.0171315 |
| spellingShingle | Gabriela Cavagnolli Ana Laura Pimentel Priscila Aparecida Correa Freitas Jorge Luiz Gross Joíza Lins Camargo Effect of ethnicity on HbA1c levels in individuals without diabetes: Systematic review and meta-analysis. PLoS ONE |
| title | Effect of ethnicity on HbA1c levels in individuals without diabetes: Systematic review and meta-analysis. |
| title_full | Effect of ethnicity on HbA1c levels in individuals without diabetes: Systematic review and meta-analysis. |
| title_fullStr | Effect of ethnicity on HbA1c levels in individuals without diabetes: Systematic review and meta-analysis. |
| title_full_unstemmed | Effect of ethnicity on HbA1c levels in individuals without diabetes: Systematic review and meta-analysis. |
| title_short | Effect of ethnicity on HbA1c levels in individuals without diabetes: Systematic review and meta-analysis. |
| title_sort | effect of ethnicity on hba1c levels in individuals without diabetes systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0171315 |
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