Multifunctional dietary approach reduces intestinal inflammation in relation with changes in gut microbiota composition in subjects at cardiometabolic risk: the SINFONI project
The development of cardiometabolic (CM) diseases is associated with chronic low-grade inflammation, partly linked to alterations of the gut microbiota (GM) and reduced intestinal integrity. The SINFONI project investigates a multifunctional (MF) nutritional strategy’s impact combining different bioa...
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Taylor & Francis Group
2025-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2024.2438823 |
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| author | Hugo Hornero-Ramirez Arianne Morissette Bruno Marcotte Armelle Penhoat Béryle Lecomte Baptiste Panthu Jacob Lessard Lord Florence Thirion Laurie Van-Den-Berghe Emilie Blond Chantal Simon Cyrielle Caussy Nathalie Feugier Joël Doré Philippe Sanoner Alexandra Meynier Yves Desjardins Geneviève Pilon André Marette Patrice D. Cani Martine Laville Sophie Vinoy Marie-Caroline Michalski Julie-Anne Nazare |
| author_facet | Hugo Hornero-Ramirez Arianne Morissette Bruno Marcotte Armelle Penhoat Béryle Lecomte Baptiste Panthu Jacob Lessard Lord Florence Thirion Laurie Van-Den-Berghe Emilie Blond Chantal Simon Cyrielle Caussy Nathalie Feugier Joël Doré Philippe Sanoner Alexandra Meynier Yves Desjardins Geneviève Pilon André Marette Patrice D. Cani Martine Laville Sophie Vinoy Marie-Caroline Michalski Julie-Anne Nazare |
| author_sort | Hugo Hornero-Ramirez |
| collection | DOAJ |
| description | The development of cardiometabolic (CM) diseases is associated with chronic low-grade inflammation, partly linked to alterations of the gut microbiota (GM) and reduced intestinal integrity. The SINFONI project investigates a multifunctional (MF) nutritional strategy’s impact combining different bioactive compounds on inflammation, GM modulation and CM profile. In this randomized crossover-controlled study, 30 subjects at CM-risk consumed MF cereal-products, enriched with polyphenols, fibers, slowly-digestible starch, omega-3 fatty acids or Control cereal-products (without bioactive compounds) for 2 months. Metabolic endotoxemia (lipopolysaccharide (LPS), lipopolysaccharide-binding protein over soluble cluster of differentiation-14 (LBP/sCD14), systemic inflammation and cardiovascular risk markers, intestinal inflammation, CM profile and response to a one-week fructose supplementation, were assessed at fasting and post mixed-meal. GM composition and metabolomic analysis were conducted. Mixed linear models were employed, integrating time (pre/post), treatment (MF/control), and sequence/period. Compared to control, MF intervention reduced intestinal inflammation (fecal calprotectin, p = 0.007) and endotoxemia (fasting LPS, p < 0.05), without alteration of systemic inflammation. MF decreased serum branched-chain amino acids compared to control (p < 0.05) and increased B.ovatus, B.uniformis, A.butyriciproducens and unclassified Christensenellaceae.CAG-74 (p < 0.05). CM markers were unchanged. A 2-month dietary intervention combining multiple bioactive compounds improved intestinal inflammation and induced GM modulation. Such strategy appears as an effective strategy to target low-grade inflammation through multi-target approach. |
| format | Article |
| id | doaj-art-8497db51c1b04ea2ba8e08a953fa5693 |
| institution | Kabale University |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-8497db51c1b04ea2ba8e08a953fa56932025-01-17T02:07:18ZengTaylor & Francis GroupGut Microbes1949-09761949-09842025-12-0117110.1080/19490976.2024.2438823Multifunctional dietary approach reduces intestinal inflammation in relation with changes in gut microbiota composition in subjects at cardiometabolic risk: the SINFONI projectHugo Hornero-Ramirez0Arianne Morissette1Bruno Marcotte2Armelle Penhoat3Béryle Lecomte4Baptiste Panthu5Jacob Lessard Lord6Florence Thirion7Laurie Van-Den-Berghe8Emilie Blond9Chantal Simon10Cyrielle Caussy11Nathalie Feugier12Joël Doré13Philippe Sanoner14Alexandra Meynier15Yves Desjardins16Geneviève Pilon17André Marette18Patrice D. Cani19Martine Laville20Sophie Vinoy21Marie-Caroline Michalski22Julie-Anne Nazare23Centre de Recherche en Nutrition Humaine - Rhône-Alpes, INSERM, INRAe, Université Claude Bernard Lyon1, Hospices Civils de Lyon, Pierre Bénite, FranceInstitute of Nutrition and Functional Foods (INAF), Faculty of Agriculture and Food Sciences, Laval University, Québec, QC, CanadaInstitute of Nutrition and Functional Foods (INAF), Faculty of Agriculture and Food Sciences, Laval University, Québec, QC, CanadaLaboratoire CarMeN, INSERM U.1060, INRAe U. 1397, Université Claude Bernard Lyon1, Pierre Bénite, FranceLaboratoire CarMeN, INSERM U.1060, INRAe U. 1397, Université Claude Bernard Lyon1, Pierre Bénite, FranceLaboratoire CarMeN, INSERM U.1060, INRAe U. 1397, Université Claude Bernard Lyon1, Pierre Bénite, FranceINRAE, MGP, Université Paris-Saclay, Jouy-en-Josas, FranceINRAE, MGP, Université Paris-Saclay, Jouy-en-Josas, FranceCentre de Recherche en Nutrition Humaine - Rhône-Alpes, INSERM, INRAe, Université Claude Bernard Lyon1, Hospices Civils de Lyon, Pierre Bénite, FranceLaboratoire CarMeN, INSERM U.1060, INRAe U. 1397, Université Claude Bernard Lyon1, Pierre Bénite, FranceCentre de Recherche en Nutrition Humaine - Rhône-Alpes, INSERM, INRAe, Université Claude Bernard Lyon1, Hospices Civils de Lyon, Pierre Bénite, FranceCentre de Recherche en Nutrition Humaine - Rhône-Alpes, INSERM, INRAe, Université Claude Bernard Lyon1, Hospices Civils de Lyon, Pierre Bénite, FranceCentre de Recherche en Nutrition Humaine - Rhône-Alpes, INSERM, INRAe, Université Claude Bernard Lyon1, Hospices Civils de Lyon, Pierre Bénite, FranceINRAE, MGP, Université Paris-Saclay, Jouy-en-Josas, FranceiSymrise-Diana Food SAS, R&D, Naturals Food & Beverage, Rennes, FranceNutrition Research, Paris-Saclay Tech Center, Mondelez International R&D, Saclay, FranceInstitute of Nutrition and Functional Foods (INAF), Faculty of Agriculture and Food Sciences, Laval University, Québec, QC, CanadaDepartment of Medicine, Faculty of Medicine, Québec Heart and Lung Institute, Université Laval, Québec, CanadaDepartment of Medicine, Faculty of Medicine, Québec Heart and Lung Institute, Université Laval, Québec, CanadaUCLouvain, Université catholique de Louvain, Louvain Drug Research Institute, (LDRI) Metabolism and Nutrition Research Group (MNUT), Brussels, BelgiumCentre de Recherche en Nutrition Humaine - Rhône-Alpes, INSERM, INRAe, Université Claude Bernard Lyon1, Hospices Civils de Lyon, Pierre Bénite, FranceNutrition Research, Paris-Saclay Tech Center, Mondelez International R&D, Saclay, FranceLaboratoire CarMeN, INSERM U.1060, INRAe U. 1397, Université Claude Bernard Lyon1, Pierre Bénite, FranceCentre de Recherche en Nutrition Humaine - Rhône-Alpes, INSERM, INRAe, Université Claude Bernard Lyon1, Hospices Civils de Lyon, Pierre Bénite, FranceThe development of cardiometabolic (CM) diseases is associated with chronic low-grade inflammation, partly linked to alterations of the gut microbiota (GM) and reduced intestinal integrity. The SINFONI project investigates a multifunctional (MF) nutritional strategy’s impact combining different bioactive compounds on inflammation, GM modulation and CM profile. In this randomized crossover-controlled study, 30 subjects at CM-risk consumed MF cereal-products, enriched with polyphenols, fibers, slowly-digestible starch, omega-3 fatty acids or Control cereal-products (without bioactive compounds) for 2 months. Metabolic endotoxemia (lipopolysaccharide (LPS), lipopolysaccharide-binding protein over soluble cluster of differentiation-14 (LBP/sCD14), systemic inflammation and cardiovascular risk markers, intestinal inflammation, CM profile and response to a one-week fructose supplementation, were assessed at fasting and post mixed-meal. GM composition and metabolomic analysis were conducted. Mixed linear models were employed, integrating time (pre/post), treatment (MF/control), and sequence/period. Compared to control, MF intervention reduced intestinal inflammation (fecal calprotectin, p = 0.007) and endotoxemia (fasting LPS, p < 0.05), without alteration of systemic inflammation. MF decreased serum branched-chain amino acids compared to control (p < 0.05) and increased B.ovatus, B.uniformis, A.butyriciproducens and unclassified Christensenellaceae.CAG-74 (p < 0.05). CM markers were unchanged. A 2-month dietary intervention combining multiple bioactive compounds improved intestinal inflammation and induced GM modulation. Such strategy appears as an effective strategy to target low-grade inflammation through multi-target approach.https://www.tandfonline.com/doi/10.1080/19490976.2024.2438823Polyphenolsomega 3endotoxemiacardiometabolic riskbranched chain amino-acidsintestinal inflammation |
| spellingShingle | Hugo Hornero-Ramirez Arianne Morissette Bruno Marcotte Armelle Penhoat Béryle Lecomte Baptiste Panthu Jacob Lessard Lord Florence Thirion Laurie Van-Den-Berghe Emilie Blond Chantal Simon Cyrielle Caussy Nathalie Feugier Joël Doré Philippe Sanoner Alexandra Meynier Yves Desjardins Geneviève Pilon André Marette Patrice D. Cani Martine Laville Sophie Vinoy Marie-Caroline Michalski Julie-Anne Nazare Multifunctional dietary approach reduces intestinal inflammation in relation with changes in gut microbiota composition in subjects at cardiometabolic risk: the SINFONI project Gut Microbes Polyphenols omega 3 endotoxemia cardiometabolic risk branched chain amino-acids intestinal inflammation |
| title | Multifunctional dietary approach reduces intestinal inflammation in relation with changes in gut microbiota composition in subjects at cardiometabolic risk: the SINFONI project |
| title_full | Multifunctional dietary approach reduces intestinal inflammation in relation with changes in gut microbiota composition in subjects at cardiometabolic risk: the SINFONI project |
| title_fullStr | Multifunctional dietary approach reduces intestinal inflammation in relation with changes in gut microbiota composition in subjects at cardiometabolic risk: the SINFONI project |
| title_full_unstemmed | Multifunctional dietary approach reduces intestinal inflammation in relation with changes in gut microbiota composition in subjects at cardiometabolic risk: the SINFONI project |
| title_short | Multifunctional dietary approach reduces intestinal inflammation in relation with changes in gut microbiota composition in subjects at cardiometabolic risk: the SINFONI project |
| title_sort | multifunctional dietary approach reduces intestinal inflammation in relation with changes in gut microbiota composition in subjects at cardiometabolic risk the sinfoni project |
| topic | Polyphenols omega 3 endotoxemia cardiometabolic risk branched chain amino-acids intestinal inflammation |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2024.2438823 |
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