Therapeutic hypothermia and neurological outcome after cardiac arrest
Introduction/Aim. The most important clinically relevant cause of global cerebral ischemia is cardiac arrest. Clinical studies showed a marked neuroprotective effect of mild hypothermia in resuscitation. The aim of this study was to evaluate the impact of mild hypothermia on neurological outcome...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2011-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2011/0042-84501106495P.pdf |
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| author | Petrović Milovan Panić Gordana Jovelić Aleksandra Čanji Tibor Srdanović Ilija Popov Tanja Golubović Miodrag |
| author_facet | Petrović Milovan Panić Gordana Jovelić Aleksandra Čanji Tibor Srdanović Ilija Popov Tanja Golubović Miodrag |
| author_sort | Petrović Milovan |
| collection | DOAJ |
| description | Introduction/Aim. The most important clinically relevant cause of global cerebral ischemia is cardiac arrest. Clinical studies showed a marked neuroprotective effect of mild hypothermia in resuscitation. The aim of this study was to evaluate the impact of mild hypothermia on neurological outcome and survival of the patients in coma, after cardiac arrest and return of spontaneous circulation. Methods. The prospective study was conducted on consecutive comatose patients admitted to our clinic after cardiac arrest and return of spontaneous circulation, between February 2005 and May 2009. The patients were divided into two groups: the patients treated with mild hypothermia and the patients treated conservatively. The intravascular in combination with external method of cooling or only external cooling was used during the first 24 hours, after which spontaneous rewarming started. The endpoints were survival rate and neurological outcome. The neurological outcome was observed with Cerebral Performance Category Scale (CPC). Follow-up was 30 days. Results. The study was conducted on 82 patients: 45 patients (age 57.93 ± 14.08 years, 77.8% male) were treated with hypothermia, and 37 patients (age 62.00 ± 9.60 years, 67.6% male) were treated conservatively. In the group treated with therapeutic hypothermia protocol, 21 (46.7%) patients had full neurological restitution (CPC 1), 3 (6.7%) patients had good neurologic outcome (CPC 2), 1 (2.2%) patient remained in coma and 20 (44.4%) patients finally died (CPC 5). In the normothermic group 7 (18.9%) patients had full neurological restitution (CPC 1), and 30 (81.1%) patients remained in coma and finally died (CPC 5). Between the two therapeutic groups there was statistically significant difference in frequencies of different neurologic outcome (p = 0.006), specially between the patients with CPC 1 and CPC 5 outcome (p = 0.003). In the group treated with mild hypothermia 23 (51.1%) patients survived, and in the normothermic group 30 (81.1%) patients died, while in the group of survived patients 23 (76.7%) were treated with mild hypothermia (p = 0.003). Conclusion. Mild therapeutic hypothermia applied after cardiac arrest improved neurological outcome and reduced mortality in the studied group of comatose survivors. |
| format | Article |
| id | doaj-art-8490c3fcf57940238d3d654f479ca80c |
| institution | DOAJ |
| issn | 0042-8450 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-8490c3fcf57940238d3d654f479ca80c2025-08-20T03:07:10ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502011-01-0168649549910.2298/VSP1106495PTherapeutic hypothermia and neurological outcome after cardiac arrestPetrović MilovanPanić GordanaJovelić AleksandraČanji TiborSrdanović IlijaPopov TanjaGolubović MiodragIntroduction/Aim. The most important clinically relevant cause of global cerebral ischemia is cardiac arrest. Clinical studies showed a marked neuroprotective effect of mild hypothermia in resuscitation. The aim of this study was to evaluate the impact of mild hypothermia on neurological outcome and survival of the patients in coma, after cardiac arrest and return of spontaneous circulation. Methods. The prospective study was conducted on consecutive comatose patients admitted to our clinic after cardiac arrest and return of spontaneous circulation, between February 2005 and May 2009. The patients were divided into two groups: the patients treated with mild hypothermia and the patients treated conservatively. The intravascular in combination with external method of cooling or only external cooling was used during the first 24 hours, after which spontaneous rewarming started. The endpoints were survival rate and neurological outcome. The neurological outcome was observed with Cerebral Performance Category Scale (CPC). Follow-up was 30 days. Results. The study was conducted on 82 patients: 45 patients (age 57.93 ± 14.08 years, 77.8% male) were treated with hypothermia, and 37 patients (age 62.00 ± 9.60 years, 67.6% male) were treated conservatively. In the group treated with therapeutic hypothermia protocol, 21 (46.7%) patients had full neurological restitution (CPC 1), 3 (6.7%) patients had good neurologic outcome (CPC 2), 1 (2.2%) patient remained in coma and 20 (44.4%) patients finally died (CPC 5). In the normothermic group 7 (18.9%) patients had full neurological restitution (CPC 1), and 30 (81.1%) patients remained in coma and finally died (CPC 5). Between the two therapeutic groups there was statistically significant difference in frequencies of different neurologic outcome (p = 0.006), specially between the patients with CPC 1 and CPC 5 outcome (p = 0.003). In the group treated with mild hypothermia 23 (51.1%) patients survived, and in the normothermic group 30 (81.1%) patients died, while in the group of survived patients 23 (76.7%) were treated with mild hypothermia (p = 0.003). Conclusion. Mild therapeutic hypothermia applied after cardiac arrest improved neurological outcome and reduced mortality in the studied group of comatose survivors.http://www.doiserbia.nb.rs/img/doi/0042-8450/2011/0042-84501106495P.pdfheart arresthypothermia, inducedneurologic manifestationstreatment outcomemortality |
| spellingShingle | Petrović Milovan Panić Gordana Jovelić Aleksandra Čanji Tibor Srdanović Ilija Popov Tanja Golubović Miodrag Therapeutic hypothermia and neurological outcome after cardiac arrest Vojnosanitetski Pregled heart arrest hypothermia, induced neurologic manifestations treatment outcome mortality |
| title | Therapeutic hypothermia and neurological outcome after cardiac arrest |
| title_full | Therapeutic hypothermia and neurological outcome after cardiac arrest |
| title_fullStr | Therapeutic hypothermia and neurological outcome after cardiac arrest |
| title_full_unstemmed | Therapeutic hypothermia and neurological outcome after cardiac arrest |
| title_short | Therapeutic hypothermia and neurological outcome after cardiac arrest |
| title_sort | therapeutic hypothermia and neurological outcome after cardiac arrest |
| topic | heart arrest hypothermia, induced neurologic manifestations treatment outcome mortality |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2011/0042-84501106495P.pdf |
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