Relative Susceptibilities of ABO Blood Groups to Plasmodium falciparum Malaria in Ghana
The clinical outcome of falciparum malaria in endemic areas is influenced by erythrocyte polymorphisms including the ABO blood groups. Studies have reported association of ABO blood group to resistance, susceptibility, and severity of P. falciparum malaria infection. Individuals with blood group “A”...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2016/5368793 |
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| author | Richmond Afoakwah Edmond Aubyn James Prah Ekene Kwabena Nwaefuna Johnson N. Boampong |
| author_facet | Richmond Afoakwah Edmond Aubyn James Prah Ekene Kwabena Nwaefuna Johnson N. Boampong |
| author_sort | Richmond Afoakwah |
| collection | DOAJ |
| description | The clinical outcome of falciparum malaria in endemic areas is influenced by erythrocyte polymorphisms including the ABO blood groups. Studies have reported association of ABO blood group to resistance, susceptibility, and severity of P. falciparum malaria infection. Individuals with blood group “A” have been found to be highly susceptible to falciparum malaria whereas blood group “O” is said to confer protection against complicated cases. We analyzed samples from 293 young children less than six years old with malaria in the Korle-Bu Teaching Hospital in Accra, Ghana. It was observed that group O was present in about 16.1% of complicated cases weighed against 40.9% of uncomplicated controls. Individuals with complicated malaria were about twice likely to be of blood groups A and B compared to group O (A versus O, OR = 1.90, 95% CI = 1.59–2.26, P<0.0001; B versus O, OR = 1.82. 95% CI = 1.57–2.23, P<0.0001). Blood group O participants with complicated diseases had low parasitaemia compared to the other blood groups (P<0.0001). This may give blood group O individuals a survival advantage over the other groups in complicated malaria as suggested. Participants with complicated falciparum malaria were generally anaemic and younger than those with uncomplicated disease. |
| format | Article |
| id | doaj-art-848ee04699b042cbb088fc21db1cfd0a |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
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| series | Advances in Hematology |
| spelling | doaj-art-848ee04699b042cbb088fc21db1cfd0a2025-02-03T01:28:12ZengWileyAdvances in Hematology1687-91041687-91122016-01-01201610.1155/2016/53687935368793Relative Susceptibilities of ABO Blood Groups to Plasmodium falciparum Malaria in GhanaRichmond Afoakwah0Edmond Aubyn1James Prah2Ekene Kwabena Nwaefuna3Johnson N. Boampong4Department of Biomedical and Forensic Sciences, University of Cape Coast, Cape Coast, GhanaDepartment of Biomedical and Forensic Sciences, University of Cape Coast, Cape Coast, GhanaUniversity Hospital, University of Cape Coast, Cape Coast, GhanaVector Genetics Laboratory, Biotechnology and Nuclear Agriculture Research Institute, Atomic Energy Commission, Accra, GhanaDepartment of Biomedical and Forensic Sciences, University of Cape Coast, Cape Coast, GhanaThe clinical outcome of falciparum malaria in endemic areas is influenced by erythrocyte polymorphisms including the ABO blood groups. Studies have reported association of ABO blood group to resistance, susceptibility, and severity of P. falciparum malaria infection. Individuals with blood group “A” have been found to be highly susceptible to falciparum malaria whereas blood group “O” is said to confer protection against complicated cases. We analyzed samples from 293 young children less than six years old with malaria in the Korle-Bu Teaching Hospital in Accra, Ghana. It was observed that group O was present in about 16.1% of complicated cases weighed against 40.9% of uncomplicated controls. Individuals with complicated malaria were about twice likely to be of blood groups A and B compared to group O (A versus O, OR = 1.90, 95% CI = 1.59–2.26, P<0.0001; B versus O, OR = 1.82. 95% CI = 1.57–2.23, P<0.0001). Blood group O participants with complicated diseases had low parasitaemia compared to the other blood groups (P<0.0001). This may give blood group O individuals a survival advantage over the other groups in complicated malaria as suggested. Participants with complicated falciparum malaria were generally anaemic and younger than those with uncomplicated disease.http://dx.doi.org/10.1155/2016/5368793 |
| spellingShingle | Richmond Afoakwah Edmond Aubyn James Prah Ekene Kwabena Nwaefuna Johnson N. Boampong Relative Susceptibilities of ABO Blood Groups to Plasmodium falciparum Malaria in Ghana Advances in Hematology |
| title | Relative Susceptibilities of ABO Blood Groups to Plasmodium falciparum Malaria in Ghana |
| title_full | Relative Susceptibilities of ABO Blood Groups to Plasmodium falciparum Malaria in Ghana |
| title_fullStr | Relative Susceptibilities of ABO Blood Groups to Plasmodium falciparum Malaria in Ghana |
| title_full_unstemmed | Relative Susceptibilities of ABO Blood Groups to Plasmodium falciparum Malaria in Ghana |
| title_short | Relative Susceptibilities of ABO Blood Groups to Plasmodium falciparum Malaria in Ghana |
| title_sort | relative susceptibilities of abo blood groups to plasmodium falciparum malaria in ghana |
| url | http://dx.doi.org/10.1155/2016/5368793 |
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