Risks and outcome of fungal infection in neutropenic children with hematologic diseases
In this retrospective study, we report the results of antifungal treatments (AFTs) in febrile neutropenic episodes in patients with acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML) and aplastic anemia (AA) in our center. From January 2004 to December 2005, a total of 52 patien...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2010-04-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/4981 |
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| author | Selin Aytaç Inci Yildirim Mehmet Ceyhan Mualla Cetin Murat Tuncer Ateş Kara A Bülent Cengiz Gülten Seçmeer Sevgi Yetgin |
| author_facet | Selin Aytaç Inci Yildirim Mehmet Ceyhan Mualla Cetin Murat Tuncer Ateş Kara A Bülent Cengiz Gülten Seçmeer Sevgi Yetgin |
| author_sort | Selin Aytaç |
| collection | DOAJ |
| description |
In this retrospective study, we report the results of antifungal treatments (AFTs) in febrile neutropenic episodes in patients with acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML) and aplastic anemia (AA) in our center. From January 2004 to December 2005, a total of 52 patients and 221 febrile neutropenic episodes were evaluated. AFT was started in 96 (43%) of the 221 episodes. Amphotericin B and fluconazole were used in 44 (46%) and 52 (54%) febrile neutropenic episodes, respectively. Microbiologically or histopathologically evident fungal infections were detected in 35 of 96 febrile neutropenic episodes. The mortality rate due to fungal infection was higher in patients with AA (7/8 patients) and AML (7/12 patients) than in ALL patients (1/32). Mortality for the whole group was 28%. When the mortality rate was compared between the two treatment groups (amphotericin B vs fluconazole), mortality was significantly higher in patients receiving amphotericin B [n = 14 (93%) and n = 1 (7%), respectively].
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| format | Article |
| id | doaj-art-848ec536ef5b450eb77b8b7f7a70c0cd |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2010-04-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-848ec536ef5b450eb77b8b7f7a70c0cd2025-08-20T03:01:11ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212010-04-01522Risks and outcome of fungal infection in neutropenic children with hematologic diseasesSelin Aytaç0Inci YildirimMehmet CeyhanMualla CetinMurat TuncerAteş KaraA Bülent CengizGülten SeçmeerSevgi YetginUnit of Hematology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey. In this retrospective study, we report the results of antifungal treatments (AFTs) in febrile neutropenic episodes in patients with acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML) and aplastic anemia (AA) in our center. From January 2004 to December 2005, a total of 52 patients and 221 febrile neutropenic episodes were evaluated. AFT was started in 96 (43%) of the 221 episodes. Amphotericin B and fluconazole were used in 44 (46%) and 52 (54%) febrile neutropenic episodes, respectively. Microbiologically or histopathologically evident fungal infections were detected in 35 of 96 febrile neutropenic episodes. The mortality rate due to fungal infection was higher in patients with AA (7/8 patients) and AML (7/12 patients) than in ALL patients (1/32). Mortality for the whole group was 28%. When the mortality rate was compared between the two treatment groups (amphotericin B vs fluconazole), mortality was significantly higher in patients receiving amphotericin B [n = 14 (93%) and n = 1 (7%), respectively]. https://turkjpediatr.org/article/view/4981 |
| spellingShingle | Selin Aytaç Inci Yildirim Mehmet Ceyhan Mualla Cetin Murat Tuncer Ateş Kara A Bülent Cengiz Gülten Seçmeer Sevgi Yetgin Risks and outcome of fungal infection in neutropenic children with hematologic diseases The Turkish Journal of Pediatrics |
| title | Risks and outcome of fungal infection in neutropenic children with hematologic diseases |
| title_full | Risks and outcome of fungal infection in neutropenic children with hematologic diseases |
| title_fullStr | Risks and outcome of fungal infection in neutropenic children with hematologic diseases |
| title_full_unstemmed | Risks and outcome of fungal infection in neutropenic children with hematologic diseases |
| title_short | Risks and outcome of fungal infection in neutropenic children with hematologic diseases |
| title_sort | risks and outcome of fungal infection in neutropenic children with hematologic diseases |
| url | https://turkjpediatr.org/article/view/4981 |
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