THYROID STATUS COMPENSATION AND CARDIOVASCULAR PARAMETERS IN PATIENTS WITH PRIMARY HYPOTHYREOSIS
Aim. To investigate the effects of primary hypothyreosis (PHT) compensation on cardiac remodelling, aortic elasticity, and vasomotor endothelial function. Material and methods. In total, 28 women with PHT were examined (age 42–78 years; median age 59,5 years). All patients underwent echocardiography...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2013-12-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/435 |
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| Summary: | Aim. To investigate the effects of primary hypothyreosis (PHT) compensation on cardiac remodelling, aortic elasticity, and vasomotor endothelial function. Material and methods. In total, 28 women with PHT were examined (age 42–78 years; median age 59,5 years). All patients underwent echocardiography and the assessment of aortic elasticity and vasomotor endothelial function using the method by Cleremajer et al. (1992). The examination took place twice, during the PHT decompensation and its compensation due to the treatment with levothyroxine sodium (on average, 3 months after the beginning of the therapy). Results. The PHT compensation was associated with a reduction in the levels of thyrotrophic hormone from 18,8 (95% confidence interval 10,7–27,0) to 2,6 (2,1–3,1) mIU/l (p<0,001) and an elevation in the levels of free thyroxin from 10,8 (9,2–12,44) to 13,7 (12,7–14,7) pmol/l (p<0,005). Left ventricular myocardial mass decreased from 192,4 (182,0–202,8) to 171,4 (160,9–181,9) g. The proportion of patients with left ventricular diastolic dysfunction decreased from 92,9 (77,4–98,0) to 71,4 (54,7–88,2)% (p<0,05), while the proportion of patients with right ventricular diastolic dysfunction decreased from 82,1 (64,4–92,1) to 25,0 (9,0–41,0)% (p<0,001). Aortic wall thickness reduced from 5,26 (4,90–5,62) to 4,53 (4,28–4,78) mm, aortic elasticity index increased from 2,26 (1,60–2,92) to 5,26 (4,36–6,15) mm 2/mm Hg, and pulse wave velocity decreased from 12,8 (11,4–14,3) to 8,42 (6,59–10,3) m/s. Relative increase in brachial artery diameter in the reactive hyperemia test, as a marker of vasomotor endothelial function, changed from 2,91 (1,69–4,14) to 9,13 (7,84–10,4)% (all p-values <0,001). Conclusion. PHT compensation is associated with reduced left ventricular myocardial mass, improved left and right ventricular function, increased aortic elasticity, and improved vasomotor endothelial function. |
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| ISSN: | 1560-4071 2618-7620 |