The non-metabolic function of 6PGD coordinates CCNA2 and HMGA2 expression to drive colorectal cancer progression and drug response

The non-metabolic function of 6PGD coordinates CCNA2 and HMGA2 expression to drive colorectal cancer progression and drug response

Abstract Emerging evidence demonstrates that the metabolic and non-metabolic functions of metabolic enzymes play a key role in tumorigenesis and progression. 6-phosphogluconate dehydrogenase (6PGD) is a key metabolic enzyme in the pentose phosphate pathway (PPP), which displays aberrant expressions...

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Main Authors: Mingming Sun, Qi Yan, Xinru Zhai, Xintong Dai, Chenxin Yang, Huifang Zhao, Sizhen Lai, Jiyan Wang, Lian Li, Zhen Li, Yanping Li, Taoyuan Wang, Tao He, Jun Xue, Zhenghu Jia, Chunze Zhang, Shuai Zhang, Changliang Shan
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Colorectal cancer (CRC)
6-phosphogluconate dehydrogenase (6PGD)
Non-metabolic activity
Proliferation
Metastasis
Online Access:https://doi.org/10.1186/s13046-025-03450-3
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